• Sleep-wake disorders

Sleep-wake disorders:

Indications for ROZEREM:



Take 8mg within 30mins of bedtime. Do not take with high-fat/heavy meals (delays effect).


Not recommended.


Concomitant fluvoxamine.


Evaluate for comorbid diagnoses. Depression. Behavioral changes. Monitor prolactin and testosterone levels if unexplained amenorrhea, galactorrhea, decreased libido, or fertility problems occur. COPD, severe obstructive sleep apnea, severe hepatic impairment: not recommended. Moderate hepatic impairment. Pregnancy. Nursing mothers: monitor infants (see full labeling).

Pharmacologic Class:

Hypnotic (melatonin agonist).


See Contraindications. Potentiated by strong inhibitors of CYP1A2, CYP3A4 (eg, ketoconazole), CYP2C9 (eg, fluconazole). Antagonized by strong CYP450 inducers (eg, rifampin). Monitor closely with donepezil, doxepin. Avoid alcohol.

Adverse Reactions:

Somnolence, dizziness, fatigue, nausea, exacerbated insomnia; complex sleep-related behaviors (eg, sleep-driving), reduced testosterone or cortisol levels, increased prolactin levels (monitor if occurs); anaphylaxis, angioedema (do not rechallenge).

How Supplied:

Tabs—30, 100, 500

Pricing for ROZEREM

8mg tablet (Qty: 30)
Appx. price $128