Hypertension:
Indications for: Reserpine
Mild essential hypertension. Adjunctive therapy with other antihypertensive agents in more severe forms of hypertenstion.
Adult Dosage:
Usual initial dose: 0.5mg daily for 1 or 2 weeks. Maintenance: reduce to 0.1–0.25mg daily.
Children Dosage:
Usually not recommended; if used, starting dose: 20mcg/kg daily; max 0.25mg daily.
Reserpine Contraindications:
Depression or history of (esp. with suicidal tendencies). Active peptic ulcer. Ulcerative colitis. Electroconvulsive therapy.
Reserpine Warnings/Precautions:
Discontinue at first signs of depression. History of peptic ulcer, ulcerative colitis, gallstones (biliary colic may be precipitated). Renal impairment. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Reserpine Classification:
Rauwolfia compound.
Reserpine Interactions:
MAOIs: avoid or use with extreme caution. Concomitant tricyclics may decrease antihypertensive effects. May potentiate direct-acting amines (eg, epinephrine, isoproterenol, phenylephrine, metaraminol). May antagonize indirect-acting amines (eg, ephedrine, tyramine, amphetamines). Caution with digoxin, quinidine, other antihypertensive agents.
Adverse Reactions:
GI upset, dry mouth, hypersecretion, arrhythmias, syncope, angina-like symptoms, bradycardia, edema, dyspnea, epistaxis, nasal congestion, dizziness, headache, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium, drowsiness, muscle aches, pseudolactation, impotence, dysuria, gynecomastia, decreased libido, weight gain, deafness, optic atrophy, glaucoma, uveitis, conjunctival injection, purpura, rash, pruritus; rare: parkinsonian syndrome and other extrapyramidal symptoms.
How Supplied:
Tabs—100, 1000, 5000
Psychosis:
Indications for: Reserpine
Relief of symptoms in agitated psychotic states (eg, schizophrenia), primarily in those unable to tolerate phenothiazine derivatives or in those who require antihypertensive medication.
Adult Dosage:
Individualize. Usual initial dose: 0.5mg daily, may range from 0.1–1mg.
Children Dosage:
Not recommended.
Reserpine Contraindications:
Depression or history of (esp. with suicidal tendencies). Active peptic ulcer. Ulcerative colitis. Electroconvulsive therapy.
Reserpine Warnings/Precautions:
Discontinue at first signs of depression. History of peptic ulcer, ulcerative colitis, gallstones (biliary colic may be precipitated). Renal impairment. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Reserpine Classification:
Rauwolfia compound.
Reserpine Interactions:
MAOIs: avoid or use with extreme caution. Concomitant tricyclics may decrease antihypertensive effects. May potentiate direct-acting amines (eg, epinephrine, isoproterenol, phenylephrine, metaraminol). May antagonize indirect-acting amines (eg, ephedrine, tyramine, amphetamines). Caution with digoxin, quinidine, other antihypertensive agents.
Adverse Reactions:
GI upset, dry mouth, hypersecretion, arrhythmias, syncope, angina-like symptoms, bradycardia, edema, dyspnea, epistaxis, nasal congestion, dizziness, headache, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium, drowsiness, muscle aches, pseudolactation, impotence, dysuria, gynecomastia, decreased libido, weight gain, deafness, optic atrophy, glaucoma, uveitis, conjunctival injection, purpura, rash, pruritus; rare: parkinsonian syndrome and other extrapyramidal symptoms.
How Supplied:
Tabs—100, 1000, 5000
