Cytoprotective and supportive care agents:

Indications for: QUADRAMET

For relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan.

Adult Dosage:

Ingest a minimum of 500mL of fluids prior to injection and void as often as possible after injection. 1mCi/kg IV over a period of 1 minute through a secure in-dwelling catheter and followed with a saline flush. Radiation dosimetry: see full labeling.

Children Dosage:

<16yrs: not established.

QUADRAMET Warnings/Precautions:

Should be administered by personnel familiar with radioactive drugs. Compromised bone marrow reserve: not recommended. Cancer patients whose platelet counts are falling or who have findings suggesting disseminated intravascular coagulation. CHF. Renal impairment. Hypocalcemia. Maintain adequate hydration. Thin or obese patients. Monitor blood counts weekly for at least 8 weeks, or until recovery of adequate bone marrow function. Incontinent patients; perform bladder catheterization to minimize radioactive contamination of patients environment. Blood or urine on clothing: wash separately or store for 1–2 weeks to allow for radioactive decay. Latex allergy. Pregnancy (Cat.D); should have negative pregnancy tests before administration; use effective contraception after administration. Nursing mothers: not recommended.

QUADRAMET Classification:

Radioactive + chelating agent.

QUADRAMET Interactions:

Concomitant chemotherapy or external beam radiation may cause additive effects on bone marrow suppression; avoid.

Adverse Reactions:

Thrombocytopenia, leukopenia, decreased hemoglobin, nausea, vomiting, fever/chills, infection, pain flare reaction, myasthenia, arrhythmias, hematuria; spinal cord compression, agranulocytosis.

How Supplied:

Single-dose vial (3mL)—1