Angina:
Indications for: Propranolol
Long-term management of angina. Hypertrophic subaortic stenosis.
Adult Dosage:
Angina: 80–320mg/day divided into 2, 3, or 4 doses. Stenosis: 20–40mg 3–4 times a day before meals and at bedtime.
Children Dosage:
Not recommended.
Propranolol Contraindications:
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Warnings/Precautions:
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Also:
Propranolol Classification:
Beta-blocker.
Propranolol Interactions:
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Adverse Reactions:
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Drug Elimination:
Renal. Half-life: 3–6hrs.
How Supplied:
Tabs—contact supplier; LA—100
CHF and arrhythmias:
Indications for: Propranolol
Atrial and ventricular arrhythmias (see literature). Tachyarrhythmia due to digitalis intoxication. In stabilized patients after MI, to reduce mortality and risk of reinfarction.
Adult Dosage:
Arrhythmias: 10–30mg 3–4 times a day before meals and at bedtime. Post-MI: 180–240mg daily in divided doses.
Children Dosage:
Not recommended.
Propranolol Contraindications:
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Warnings/Precautions:
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Propranolol Classification:
Beta-blocker.
Propranolol Interactions:
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Adverse Reactions:
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Drug Elimination:
Renal. Half-life: 3–6hrs.
How Supplied:
Tabs 60mg—100; 10mg, 20mg, 40mg, 80mg—100, 5000
Hypertension:
Indications for: Propranolol
Hypertension. Adjunct in pheochromocytoma.
Adult Dosage:
Initially 40mg twice a day. Usual maintenance: 120–240mg daily; max 640mg daily. Pheochromocytoma: 60mg daily in divided doses for 3 days pre-op or 30mg daily in inoperable cases.
Children Dosage:
Initially 1mg/kg daily. Usual range: 2–4mg/kg per day in 2 divided doses; max 16mg/kg per day.
Propranolol Contraindications:
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Warnings/Precautions:
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Also:
Propranolol Classification:
Beta-blocker.
Propranolol Interactions:
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Adverse Reactions:
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Drug Elimination:
Renal. Half-life: 3–6hrs.
How Supplied:
Tabs—contact supplier; LA—100
Migraine and headache:
Indications for: Propranolol
Migraine prophylaxis.
Adult Dosage:
Initially 80mg daily in divided doses. Usual range: 160–240mg daily. Discontinue if poor result after 4–6 weeks.
Children Dosage:
Not recommended.
Propranolol Contraindications:
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Warnings/Precautions:
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Also:
Propranolol Classification:
Beta-blocker.
Propranolol Interactions:
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Adverse Reactions:
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Drug Elimination:
Renal. Half-life: 3–6hrs.
How Supplied:
Tabs—contact supplier; LA—100
