Allergies:
Indications for: Promethazine HCl Injection
Allergic reactions to blood or plasma. Uncomplicated allergic conditions of the immediate type where oral therapy is impossible or contraindicated. Adjunct in anaphylaxis.
Adult Dosage:
25mg IM or IV, if 2nd dose is needed, may repeat after 2 hours. Switch to oral form as soon as possible
Children Dosage:
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).
Promethazine HCl Injection Contraindications:
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine HCl Injection Warnings/Precautions:
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine HCl Injection Classification:
Phenothiazine.
Promethazine HCl Injection Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Adverse Reactions:
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Note:
Formerly known under the brand name Phenergan.
How Supplied:
Contact supplier.
Nausea:
Indications for: Promethazine HCl Injection
Motion sickness. Prevention and treatment of nausea & vomiting with anesthesia and surgery.
Adult Dosage:
12.5–25mg IM or IV every 4 hours.
Children Dosage:
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature). Should not be used in vomiting of unknown etiology in children and adolescents.
Promethazine HCl Injection Contraindications:
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine HCl Injection Warnings/Precautions:
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine HCl Injection Classification:
Phenothiazine.
Promethazine HCl Injection Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Adverse Reactions:
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Note:
Formerly known under the brand name Phenergan.
How Supplied:
Contact supplier.
Nonnarcotic analgesics:
Indications for: Promethazine HCl Injection
Adjunct to analgesics for control of postoperative pain. Special surgical situations (i.e. bronchoscopy, ophthalmic surgery, poor risk patients) to reduce amounts of narcotic analgesic as an adjunct to anesthesia and analgesia.
Adult Dosage:
25–50mg IM or IV.
Children Dosage:
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).
Promethazine HCl Injection Contraindications:
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine HCl Injection Warnings/Precautions:
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine HCl Injection Classification:
Phenothiazine.
Promethazine HCl Injection Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Adverse Reactions:
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Note:
Formerly known under the brand name Phenergan.
How Supplied:
Contact supplier.
Sleep-wake disorders:
Indications for: Promethazine HCl Injection
For light sedation and relief of apprehension. Obstetric (during labor), pre- and post-operative sedation.
Adult Dosage:
Sedation: 25–50mg IM or IV. Obstetric: 50mg IM or IV in early stages of labor; 25–75mg IM or IV when labor is established; may repeat once or twice at 4 hour intervals; max 100mg/day. Pre- and post-op: 25–50mg IM or IV.
Children Dosage:
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).
Promethazine HCl Injection Contraindications:
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine HCl Injection Warnings/Precautions:
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine HCl Injection Classification:
Phenothiazine.
Promethazine HCl Injection Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Adverse Reactions:
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Note:
Formerly known under the brand name Phenergan.
How Supplied:
Contact supplier.
