Gout:
Indications for: Probenecid
Hyperuricemia associated with gout and gouty arthritis.
Adult Dosage:
250mg twice daily for 1 week, then 500mg twice daily thereafter. Renal impairment, dose adjustments: see literature.
Children Dosage:
Not recommended.
Probenecid Contraindications:
Acute gouty attack. Blood dyscrasias. Uric acid kidney stones. Children <2 yrs of age. Concomitant salicylates (antagonizes uricosuric effect).
Probenecid Warnings/Precautions:
History of peptic ulcer. Renal insufficiency. G6PD deficiency. Maintain adequate hydration. Alkalization of urine may be required. Pregnancy.
Probenecid Classification:
Uricosuric.
Probenecid Interactions:
Affects renal clearance of many drugs (esp. penicillins). Potentiates methotrexate (monitor and reduce methotrexate dose). May potentiate thiopental, ketamine, NSAIDs, oral sulfonylureas, acetaminophen, lorazepam, rifampin, other sulfonamides. Pyrazinamide antagonizes uricosuric effect. May cause falsely high readings of theophylline levels.
Adverse Reactions:
Headache, dizziness, GI upset, urinary frequency, sore gums, uric acid kidney stones, dermatitis, fever, hematuria, renal colic, blood dyscrasias, hemolytic anemia; rare: severe allergic reactions, anaphylaxis.
Note:
Formerly known under the brand name Benemid.
How Supplied:
Contact supplier.
