Corticosteroid-responsive disorders:

Indications for: Prednisolone Oral Solution 15mg/5mL

Corticosteroid-responsive disorders.

Adult Dosage:

See full labeling. Initially 5–60mg daily.

Children Dosage:

See full labeling. Initially 0.14–2mg/kg/day in 3 or 4 divided doses.

Prednisolone Oral Solution 15mg/5mL Contraindications:

Systemic fungal infections. Live vaccines.

Prednisolone Oral Solution 15mg/5mL Warnings/Precautions:

Systemic fungal infections, cerebral malaria, optic neuritis: not recommended. Tuberculosis. Latent amebiasis. Strongyloides infestation. Ocular herpes simplex. May increase risk and mask signs of infection. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. HPA axis suppression. Cushing’s syndrome. Hyperglycemia. Thyroid disorders. Hypertension. CHF. Renal insufficiency. Recent MI. Risk of GI perforation. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Osteoporosis. Kaposi’s sarcoma. May cause electrolyte imbalances or psychotic manifestations. Avoid abrupt cessation. Monitor weight, growth, BP, IOP, fluid and electrolyte balance. Elderly. Pregnancy (Cat.D). Nursing mothers.

See Also:

Prednisolone Oral Solution 15mg/5mL Classification:

Glucocorticoid.

Prednisolone Oral Solution 15mg/5mL Interactions:

See Contraindications. Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens. Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbama-zepine, rifampin), cholestyramine, aminoglutethimide. May potentiate cyclosporine. May antagonize anticoagulants (monitor), isoniazid. Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Increased GI effects with aspirin or NSAIDs. Caution with aspirin in hypoprothrombinemia. Monitor for hypokalemia with potassium-depleting drugs. Withdraw anticholinesterase agents at least 24hrs before initiating therapy. May suppress reactions to skin tests.

Adverse Reactions:

HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.

How Supplied:

Soln (25mg/5mL)—8oz; 15mg/5mL—contact supplier