Topical pain relief:
Indications for: PLIAGLIS
Local analgesia for superficial dermatological procedures (eg, dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, laser-assisted tattoo removal).
Adult Dosage:
Do not exceed recommended dose or duration. Apply to intact skin prior to procedure; spread evenly and thinly across treatment area using a metal spatula or tongue depressor. Dermal filler inj or facial laser ablation: apply for 20–30mins. Laser-assisted tattoo removal: apply for 60mins. Amount (length) to apply: see full labeling.
Children Dosage:
Not established.
PLIAGLIS Contraindications:
PABA hypersensitivity.
PLIAGLIS Warnings/Precautions:
Risk of methemoglobinemia (esp. in G6PD deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6 months of age, concurrent exposure to oxidizing agents or metabolites); monitor. Avoid overexposure. Severe hepatic disease. Pseudocholinesterase deficiency. Risks of secondary exposure to children and pets; may be toxic. Avoid contact with eyes, mucous membranes, or areas with a compromised skin barrier (eg, broken or inflamed). Acutely ill. Debilitated. Elderly. Pregnancy. Nursing mothers.
PLIAGLIS Classification:
Topical anesthetic (amide-type + ester-type).
PLIAGLIS Interactions:
Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, others. Toxicity may be potentiated by Class I antiarrhythmics (eg, tocainide, mexiletine); caution. Additive effects with other products containing local anesthetics; consider the amount absorbed from all formulations.
Adverse Reactions:
Localized reactions (eg, erythema, skin discoloration, edema), allergic reactions (eg, urticaria, angioedema, bronchospasm, shock).
Drug Elimination:
Lidocaine: renal.
Generic Drug Availability:
NO
How Supplied:
Cream—30g
