Thromboembolic disorders:
Indications for: PLAVIX
To reduce the rate of MI and stroke in patients with: non-ST-segment elevation acute coronary syndrome (unstable angina/non-ST-elevation MI) or acute ST-elevation MI; history of recent MI, recent stroke, or established peripheral arterial disease; see full labeling.
Adult Dosage:
Acute coronary syndrome (give with aspirin): initially give one 300mg loading dose, then continue at 75mg once daily. Recent MI, recent stroke, or established peripheral arterial disease: 75mg once daily without a loading dose.
Children Dosage:
Not established.
PLAVIX Contraindications:
Active pathologic bleeding (eg, peptic ulcer, intracranial hemorrhage).
Boxed Warning:
Diminished antiplatelet effect in patients with two loss-of-function alleles of the CYP2C19 gene.
PLAVIX Warnings/Precautions:
CYP2C19 poor metabolizers: diminished effectiveness in those who are homozygous for nonfunctional alleles of the CYP2C19 gene. Perform testing for the CYP2C19 genotype before starting therapy; consider alternative treatment if identified. Increased risk of bleeding. Premature discontinuation increases risk of cardiovascular events; if temporarily discontinued (eg, to treat bleeding or surgery; if possible, interrupt therapy for 5 days before such surgery); restart as soon as possible. Moderate and severe renal impairment. Pregnancy. Labor & delivery: discontinue 5–7 days prior to labor, delivery, or neuraxial blockade. Nursing mothers.
PLAVIX Classification:
P2Y12 platelet inhibitor (thienopyridine).
PLAVIX Interactions:
Avoid concomitant CYP2C19 inhibitors (eg, omeprazole, esomeprazole) or strong CYP2C19 inducers (eg, rifampin). Antagonized by opioid agonists (eg, morphine, others); consider using IV anti-platelet agent instead. Caution with concomitant other drugs that increase risk of bleeding (eg, NSAIDs, warfarin, SSRIs, SNRIs, other antiplatelet agents); evaluate for blood loss if concomitant with other antiplatelets. Avoid concomitant repaglinide; if unavoidable, initiate repaglinide at 0.5mg before each meal; max 4mg/day; monitor glucose frequently.
Adverse Reactions:
Bleeding (may be fatal), epistaxis, hematuria, bruising, ulcers, rash; hypersensitivity reactions, thrombotic thrombocytopenic purpura.
Generic Drug Availability:
YES
How Supplied:
Tabs 75mg—90; 300mg—30
