Nausea:
Indications for: Perphenazine
Severe nausea and vomiting.
Adult Dosage:
8–16mg/day in divided doses; may use 24mg, if needed. Reduce dose as soon as possible.
Children Dosage:
Not recommended.
Perphenazine Contraindications:
Coma. Concomitant large doses of CNS depressants. Blood dyscrasias. Bone marrow depression. Liver damage. Subcortical brain damage.
Perphenazine Warnings/Precautions:
CNS depression. Epilepsy. Cardiovascular disease. Respiratory disorders. History of breast cancer. Pheochromocytoma. Avoid sun, exposure to extreme heat or phosphorus insecticides. Surgery: consider lower anesthetic dose. Monitor blood, hepatic, and renal function. Write ℞ for smallest practical amounts. Reevaluate periodically. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.
Perphenazine Classification:
Piperazinyl phenothiazine.
Perphenazine Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsant doses. Additive anticholinergic effects with atropine or related-drugs.
Adverse Reactions:
Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, ECG changes, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, adynamic ileus, hyperprolactinemia, extrapyramidal reactions, neuroleptic malignant syndrome.
Note:
Formerly known under the brand name Trilafon.
How Supplied:
Contact supplier.
Psychosis:
Indications for: Perphenazine
Manifestations of psychotic disorders.
Adult Dosage:
Nonhospitalized: initially 4–8mg 3 times daily; then reduce to lowest effective dose. Hospitalized: 8–16mg 2–4 times daily; max 64mg per day.
Children Dosage:
Not recommended.
Perphenazine Contraindications:
Coma. Concomitant large doses of CNS depressants. Blood dyscrasias. Bone marrow depression. Liver damage. Subcortical brain damage.
Perphenazine Warnings/Precautions:
CNS depression. Epilepsy. Cardiovascular disease. Respiratory disorders. History of breast cancer. Pheochromocytoma. Avoid sun, exposure to extreme heat or phosphorus insecticides. Surgery: consider lower anesthetic dose. Monitor blood, hepatic, and renal function. Write ℞ for smallest practical amounts. Reevaluate periodically. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.
Perphenazine Classification:
Piperazinyl phenothiazine.
Perphenazine Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsant doses. Additive anticholinergic effects with atropine or related-drugs.
Adverse Reactions:
Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, ECG changes, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, adynamic ileus, hyperprolactinemia, extrapyramidal reactions, neuroleptic malignant syndrome.
Note:
Formerly known under the brand name Trilafon.
How Supplied:
Contact supplier.
