Intermittent claudication:

Indications for: Pentoxifylline

Intermittent claudication.

Adult Dosage:

400mg three times daily with meals. Continue for at least 8 weeks. Digestive or CNS effects: lower dosage to 400mg twice daily; discontinue if side effects persist. Severe renal impairment (CrCl <30mL/min): 400mg once daily.

Children Dosage:

Not established.

Pentoxifylline Contraindications:

Recent cerebral or retinal hemorrhage. Methylxanthines intolerance (eg, caffeine, theophylline, theobromine).

Pentoxifylline Warnings/Precautions:

Discontinue if anaphylactic/anaphylactoid reaction occurs. Monitor for bleeding including hematocrit, hemoglobin in patients with hemorrhagic risk factors (eg, recent surgery, peptic ulcer, cerebral and/or retinal bleeding). Renal or hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pentoxifylline Classification:

Hemorrheologic agent (xanthine).

Pentoxifylline Interactions:

See Contraindications. May potentiate antihypertensives; monitor BP. Concomitant theophylline-containing drugs; monitor closely and adjust dose. Bleeding with concomitant NSAIDs, anticoagulants, or platelet aggregation inhibitors. Concomitant warfarin; monitor PT frequently. May be potentiated by strong CYP1A2 inhibitors (eg, ciprofloxacin, fluvoxamine), cimetidine.

Adverse Reactions:

GI upset, nausea, dyspepsia, flushing, agitation, headache, dizziness, insomnia, blurred vision.


Formerly known under the brand name Trental.



Drug Elimination:

Renal (primarily), fecal.

How Supplied:

Contact supplier