Colorectal disorders:
Indications for: PENTASA
Mildly to moderately active ulcerative colitis.
Adult Dosage:
Swallow whole; may open caps and sprinkle entire contents onto applesauce or yogurt, consume immediately. 1g four times daily for up to 8 weeks.
Children Dosage:
Not established.
PENTASA Warnings/Precautions:
Sulfasalazine allergy. Discontinue if acute intolerance syndrome is suspected. Conditions predisposing to myocarditis or pericarditis. Atopic dermatitis or eczema: may have more severe photosensitivity reactions. Nephrolithiasis. Ensure adequate hydration. Renal or hepatic impairment. Monitor renal function prior to and periodically during therapy. Elderly (monitor CBCs, platelets). Pregnancy. Nursing mothers: monitor infants.
PENTASA Classification:
Salicylate.
PENTASA Interactions:
Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk for blood disorders, bone marrow failure, and associated complications with azathioprine or 6-mercaptopurine and/or other drugs known to cause myelotoxicity. May cause elevated test results in measuring urinary normetanephrine; consider alternative assay.
Adverse Reactions:
Diarrhea, headache, nausea, abdominal pain, dyspepsia, vomiting, rash; renal impairment, acute intolerance syndrome, hypersensitivity reactions (including myocarditis, pericarditis, pneumonitis, hematologic abnormalities, others); discontinue if occurs.
Generic Drug Availability:
NO
How Supplied:
Caps 250mg—240; 500mg—120
