Parkinsonism:
Indications for: NEUPRO
Idiopathic Parkinson's disease.
Adult Dosage:
Apply to clean, dry, intact skin on abdomen, thigh, hip, flank, shoulder, or upper arm. Early-stage: initially 2mg/24hrs patch once daily; may increase weekly by 2mg/24hrs if needed; max 6mg/24hrs once daily. Advanced-stage: initially 4mg/24hrs patch once daily; may increase weekly by 2mg/24hrs if needed; max 8mg/24hrs once daily. Rotate application site (allow 14 days before reapplying to same site). Shave site at least 3 days before application if hairy. Avoid abrupt cessation; reduce by 2mg/24hrs every other day.
Children Dosage:
Not established.
NEUPRO Warnings/Precautions:
Avoid external heat sources. Remove patch before cardioversion, MRI. Consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Sleep disorder. Psychotic disorder. Increased risk of symptomatic hypotension; monitor BP esp. during dose adjustments. Cardiovascular disease. Conditions aggravated by fluid retention (eg, CHF, renal insufficiency); monitor for weight gain. Consider dose reduction or discontinuation if urges/compulsive behaviors develop. Asthma. Sulfite sensitivity. Pre-existing dyskinesia. Potential withdrawal symptoms; monitor during and after discontinuation. Severe hepatic impairment. Pregnancy. Nursing mothers: may inhibit lactation.
NEUPRO Classification:
Dopamine agonist (non-ergot).
NEUPRO Interactions:
Caution with concomitant alcohol, sedating drugs or other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be antagonized by metoclopramide, antipsychotics.
Adverse Reactions:
Nausea, vomiting, somnolence (may be sudden), application site reactions, dizziness, anorexia, hyperhidrosis, insomnia, peripheral edema, dyskinesia; orthostatic hypotension, syncope, hallucinations, psychotic-like behavior, intense urges/compulsions, hypertension, heart rate elevation.
Generic Drug Availability:
NO
How Supplied:
Patches—30
Restless legs syndrome:
Indications for: NEUPRO
Moderate to severe primary restless legs syndrome (RLS).
Adult Dosage:
Apply to clean, dry, intact skin on abdomen, thigh, hip, flank, shoulder, or upper arm. Initially 1mg/24hrs patch once daily; may increase weekly by 1mg/24hrs if needed; max 3mg/24hrs once daily. Rotate application site (allow 14 days before reapplying to same site). Shave site at least 3 days before application if hairy. Avoid abrupt cessation; reduce by 1mg/24hrs every other day.
Children Dosage:
Not established.
NEUPRO Warnings/Precautions:
Avoid external heat sources. Remove patch before cardioversion, MRI. Consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Sleep disorder. Psychotic disorder. Increased risk of symptomatic hypotension; monitor BP esp. during dose adjustments. Cardiovascular disease. Conditions aggravated by fluid retention (eg, CHF, renal insufficiency); monitor for weight gain. Consider dose reduction or discontinuation if urges/compulsive behaviors develop. Asthma. Sulfite sensitivity. Pre-existing dyskinesia. Potential withdrawal symptoms; monitor during and after discontinuation. Severe hepatic impairment. Pregnancy. Nursing mothers: may inhibit lactation.
NEUPRO Classification:
Dopamine agonist (non-ergot).
NEUPRO Interactions:
Caution with concomitant alcohol, sedating drugs or other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be antagonized by metoclopramide, antipsychotics.
Adverse Reactions:
Nausea, vomiting, somnolence (may be sudden), application site reactions, headache, dizziness, anorexia, hyperhidrosis, insomnia, peripheral edema, dyskinesia; orthostatic hypotension, syncope, hallucinations, psychotic-like behavior, intense urges/compulsions, hypertension, heart rate elevation, augmentation/rebound of RLS symptoms.
Generic Drug Availability:
NO
How Supplied:
Patches—30
