Sleep-wake disorders:

Indications for: NEMBUTAL

Short-term (≤ 2 weeks) treatment of insomnia when oral route is not feasible.

Adult Dosage:

IM: 150mg–200mg (max 5mL/inj) as a single deep IM inj. IV: Inject slowly (max 50mg/min). ≥70kg: initially 100mg; observe and monitor vital signs at least 1 minute, then may increase as needed in small increments to usual max 500mg. Elderly, debilitated, renal or hepatic impairment: reduce dose.

Children Dosage:

IM: 2–6mg/kg as a single deep IM inj; max 100mg. IV: inject slowly; reduce adult dose proportionally (see literature).

NEMBUTAL Contraindications:


NEMBUTAL Warnings/Precautions:

Prehepatic coma: not recommended. Avoid abrupt cessation. Acute or chronic pain. Depression. Suicidal tendencies. Drug abuser. Hepatic or renal impairment. Monitor BP, respiration, cardiac function. Avoid extravasation. Write ℞ for smallest practical amount. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D). Nursing mothers.

NEMBUTAL Classification:


NEMBUTAL Interactions:

Potentiated by MAOIs, valproic acid, sodium valproate (monitor). CNS depression potentiated with alcohol, other CNS depressants. Antagonizes anticoagulants, corticosteroids, other steroid hormones (eg, oral contraceptives), doxycycline. May interfere with griseofulvin absorption. Variable effects with phenytoin (monitor).

Adverse Reactions:

Somnolence, respiratory depression, CNS effects, bradycardia, hypotension, syncope, GI upset, headache, inj site reactions, paradoxical excitement.

How Supplied:

Multi-dose vials (20mL, 50mL)—1