Indications for: Naltrexone

Adjunct in treatment of alcohol or narcotic dependence.

Adult Dosage:

Confirm 7–10 day opioid-free period, if questionable do Narcan challenge test (see full labeling). ≥18yrs: Alcoholism: 50mg daily. Narcotic dependence: Initially 25mg, if no withdrawal symptoms increase to 50mg daily; alternative dosing schedules: see full labeling.

Children Dosage:

<18yrs: not recommended.

Naltrexone Contraindications:

Concomitant opioids, current opioid dependence, or acute opioid withdrawal. Failed Narcan challenge test or (+) urine screen for opioids. Acute hepatitis. Liver failure.

Naltrexone Warnings/Precautions:

Liver disease. Monitor liver function. Warn patients of danger of attempting to overcome opiate blockade. Severe renal dysfunction. Possible acute abstinence syndrome. Depression. Suicidal ideation. Pregnancy (Cat.C). Nursing mothers.

Naltrexone Classification:

Opioid antagonist.

Naltrexone Interactions:

Thioridazine increases sedation. Antagonizes opioids (eg, antitussives, antidiarrheals, analgesics). Disulfiram.

Adverse Reactions:

Hepatotoxicity, withdrawal reactions; others, see full labeling.


Formerly known under the brand name Revia.

How Supplied:

Contact supplier