Acne:
Indications for: Minocycline
Adjunct in severe acne.
Adult Dosage:
Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily.
Children Dosage:
≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours.
Minocycline Warnings/Precautions:
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. Pregnancy, nursing mothers: not recommended.
Minocycline Classification:
Tetracycline antibiotic.
Minocycline Interactions:
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test.
Adverse Reactions:
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe).
Note:
Formerly known under the brand name Dynacin.
How Supplied:
Contact supplier
Bacterial infections:
Indications for: Minocycline
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax due to B. anthracis.
Adult Dosage:
Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Syphilis: treat for 10–15 days. Meningococcal carrier state: 100mg every 12 hours for 5 days. Mycobacterium marinum infection: 100mg every 12 hours for 6–8 weeks has been used. Uncomplicated urethral, endocervical, or rectal infection w. C.trachomatis or U. urealyticum: 100mg every 12 hours for at least 7 days. For men: Uncomplicated gonococcal infection (not urethritis or anorectal): 200mg once then 100mg every 12 hours for at least 4 days; urethritis: 100mg every 12 hours for 5 days.
Children Dosage:
≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours.
Minocycline Warnings/Precautions:
Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. Pregnancy, nursing mothers: not recommended.
Minocycline Classification:
Tetracycline antibiotic.
Minocycline Interactions:
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test.
Adverse Reactions:
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe).
Note:
Formerly known under the brand name Dynacin.
How Supplied:
Contact supplier
