Acne:
Indications for: MINOCIN for INJECTION
Adjunct in severe acne.
Adult Dosage:
Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children Dosage:
≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
MINOCIN for INJECTION Warnings/Precautions:
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
See Also:
MINOCIN for INJECTION Classification:
Tetracycline antibiotic.
MINOCIN for INJECTION Interactions:
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Adverse Reactions:
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
How Supplied:
Caps—60; Single-use vials—1, 10
Bacterial infections:
Indications for: MINOCIN for INJECTION
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax due to B. anthracis.
Adult Dosage:
Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children Dosage:
≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
MINOCIN for INJECTION Warnings/Precautions:
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
See Also:
MINOCIN for INJECTION Classification:
Tetracycline antibiotic.
MINOCIN for INJECTION Interactions:
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Adverse Reactions:
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
How Supplied:
Caps—60; Single-use vials—1, 10
Protozoal infections:
Indications for: MINOCIN for INJECTION
Adjunct in acute intestinal amebiasis.
Adult Dosage:
Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children Dosage:
≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
MINOCIN for INJECTION Warnings/Precautions:
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
See Also:
MINOCIN for INJECTION Classification:
Tetracycline antibiotic.
MINOCIN for INJECTION Interactions:
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Adverse Reactions:
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
How Supplied:
Caps—60; Single-use vials—1, 10
