Hypotension:
Indications for: Midodrine
Symptomatic orthostatic hypotension.
Adult Dosage:
Take during the day while upright; allow at least 4 hours between last dose and bedtime. 10mg 3 times daily at 3–4 hour intervals. Renal dysfunction: initially 2.5mg 3 times daily. Discontinue if no improvement after initial therapy.
Children Dosage:
Not established.
Midodrine Contraindications:
Severe heart disease. Acute renal disease. Urinary retention. Pheochromocytoma. Thyrotoxicosis. Persistent, excessive supine hypertension.
Midodrine Warnings/Precautions:
Initial supine systolic pressure >180mmHg: not recommended. Monitor supine and sitting BP. Discontinue if supine hypertension occurs. Diabetes. Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers.
Midodrine Classification:
Alpha-1 agonist.
Midodrine Interactions:
Avoid concomitant drugs that increase BP (eg, phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, droxidopa); if unavoidable, monitor BP closely. Avoid concomitant MAO inhibitors or linezolid. Potentiated by sodium-retaining steroids (eg, fludrocortisone acetate); caution in increased intraocular pressure with fludrocortisone. Antagonized by α-antagonists (eg, prazosin, terazosin, doxazosin). Levels may be affected by renally-excreted alkaline drugs (eg, metformin, cimetidine, ranitidine, procainamide, triamterene, flecainide, quinidine). Cardiac glycosides, β-blockers, CNS drugs may cause bradycardia, AV block, arrhythmias; discontinue if bradycardia occurs.
Adverse Reactions:
Paresthesia, piloerection, dysuria, pruritus, supine hypertension, chills, pain, rash.
Note:
Formerly known under the brand name Proamatine.
How Supplied:
Contact supplier.
