Indications for: MICROZIDE


Adult Dosage:

12.5mg once daily; usual max 50mg/day.

Children Dosage:

Not established.

MICROZIDE Contraindications:

Anuria. Sulfonamide allergy.

MICROZIDE Warnings/Precautions:

Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Parathyroid disease. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Elderly. Pregnancy. Nursing mothers: not recommended.

MICROZIDE Classification:

Diuretic (thiazide).

MICROZIDE Interactions:

May cause digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests. Additive effects with other antihypertensives.

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values; acute myopia, angle-closure glaucoma (discontinue if occurs), increased risk for non-melanoma skin cancer.

How Supplied: