Miscellaneous diagnostic tests:
Indications for: METOPIRONE
Diagnostic drug for testing hypothalamic-pituitary ACTH function.
Adult Dosage:
Single-dose short test: 30mg/kg (max 3g) at midnight with yogurt or milk. Blood sample for assay taken early the following morning. Give prophylactic dose of cortisone acetate 50mg. Multiple-dose test: Testing done over 6-day period. Administer 750mg every 4 hours for 6 doses on Day 5. See literature for results interpretation.
Children Dosage:
Single-dose short test: 30mg/kg (max 3g) at midnight with yogurt or milk. Blood sample for assay taken early the following morning. Give prophylactic dose of cortisone acetate 50mg. Multiple-dose test: Testing done over 6-day period. Administer 15mg/kg every 4 hours for 6 doses on Day 5. A minimum single dose of 250mg is recommended. See literature for results interpretation.
METOPIRONE Contraindications:
Adrenal cortical insufficiency.
METOPIRONE Warnings/Precautions:
May induce acute adrenal insufficiency in patients with reduced adrenal secretory capacity. Hypo- or hyperthyroidism. Pregnancy (Cat.C). Nursing mothers.
METOPIRONE Classification:
Adrenal corticosteroid synthesis inhibitor.
METOPIRONE Interactions:
Discontinue drugs affecting pituitary and adrenocortical function prior to and during testing. May be antagonized by phenytoin; test may be inaccurate in patients taking phenytoin 2 weeks prior. Subnormal response with estrogen therapy. May potentiate acetaminophen toxicity.
Adverse Reactions:
Hypotension, GI upset, abdominal pain, headache, dizziness, sedation, rash; rare: decreased WBC, bone marrow depression.
How Supplied:
Caps—18
