Anorexia/cachexia:
Indications for: MEGACE ES
Anorexia, cachexia, or unexplained significant weight loss in patients diagnosed with AIDS.
Limitations of Use:
Should only be instituted after treatable causes of weight loss are sought and addressed. Not for prophylactic use to avoid weight loss.
Adult Dosage:
625mg/5mL per day.
Children Dosage:
Not established.
MEGACE ES Contraindications:
Pregnancy.
MEGACE ES Warnings/Precautions:
Do not substitute with other megestrol suspensions (not interchangeable). History of thromboembolic disease. Monitor for signs/symptoms of adrenal insufficiency; consider empiric therapy if occurs. Diabetes. Renal impairment. Elderly. Fetal toxicity. Obtain (–) pregnancy test prior to initiation. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: not recommended.
MEGACE ES Classification:
Progestin.
MEGACE ES Interactions:
May increase insulin requirements. Decreases indinavir levels.
Adverse Reactions:
Nausea, diarrhea, impotence, rash, flatulence, hypertension, asthenia; rare: adrenal insufficiency, breakthrough bleeding.
Generic Drug Availability:
YES
How Supplied:
Concentrated susp (125mg/mL)—5oz
