Mood disorders:

Indications for: Maprotiline HCl

Treatment of depressive illness in patients with depressive neurosis (dysthymic disorder) and manic-depressive illness, depressed type (major depressive disorder). Relief of anxiety associated with depression.

Adult Dosage:

Mild-moderate depression: initially 75mg daily; maintain for 2 weeks, may increase in 25mg increments as required and tolerated. Usual max 150mg daily. Severely depressed or hospitalized: initially 100–150mg daily; may increase to max 225mg daily if necessary. Maintenance: use lowest effective dose; may be reduced to 75–150mg daily; adjust as needed. Elderly (>60yrs): initially 25mg daily; maintenance therapy: 50–75mg daily.

Children Dosage:

<18yrs: not recommended.

Maprotiline HCl Contraindications:

Seizure disorder. Within 14 days of MAOIs. Acute phase of MI.

Maprotiline HCl Warnings/Precautions:

History of MI. Cardiovascular disease. Discontinue prior to elective surgery. Increased intraocular pressure. Urinary retention. Narrow-angle glaucoma. Hyperthyroidism. Monitor leukocyte and differential counts in patients who develop fever and sore throat; discontinue if evidence of pathological neutrophil depression. Write ℞ for smallest amount needed. Pregnancy (Cat.B). Nursing mothers.

Maprotiline HCl Classification:


Maprotiline HCl Interactions:

See Contraindications. Potentiates CNS depression with concomitant alcohol, barbiturates, other CNS depressants. Additive atropine-like effects with anticholinergics, sympathomimetics. Avoid concomitant electroshock therapy. Potential for cardiovascular toxicity with thyroid drugs. May antagonize guanethidine. Concomitant phenothiazines, or rapid tapering of benzodiazepines: increased risk of seizures. May be potentiated by hepatic enzyme inhibitors (eg, cimetidine, fluoxetine). May be antagonized by hepatic enzyme inducers (eg, barbiturates, phenytoin).

Adverse Reactions:

Drowsiness, dry mouth, nervousness, dizziness, constipation, blurred vision, tremor, GI upset, anxiety, insomnia, weakness, fatigue, headache, agitation.


Formerly known under the brand name Ludiomil.

How Supplied: