Colorectal disorders:
Indications for: LINZESS
Irritable bowel syndrome with constipation (IBS-C).
Adult Dosage:
Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 290mcg once daily.
Children Dosage:
<2yrs: contraindicated. 2–<18yrs: not established.
LINZESS Contraindications:
Children <2yrs old. Known or suspected mechanical GI obstruction.
Boxed Warning:
Risk of serious dehydration in pediatric patients <2yrs of age.
LINZESS Warnings/Precautions:
Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.
LINZESS Classification:
Guanylate cyclase-C agonist.
Adverse Reactions:
Diarrhea, abdominal pain, flatulence, abdominal distention.
Drug Elimination:
Fecal.
Generic Drug Availability:
NO
How Supplied:
Caps—30
Constipation and bowel cleansers:
Indications for: LINZESS
Chronic idiopathic constipation (CIC).
Adult Dosage:
Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 145mcg once daily. A dosage of 72mcg once daily may be used based on individual presentation or tolerability.
Children Dosage:
<2yrs: contraindicated. 2–<18yrs: not established.
LINZESS Contraindications:
Children <2yrs old. Known or suspected mechanical GI obstruction.
Boxed Warning:
Risk of serious dehydration in pediatric patients <2yrs of age.
LINZESS Warnings/Precautions:
Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.
LINZESS Classification:
Guanylate cyclase-C agonist.
Adverse Reactions:
Diarrhea, abdominal pain, flatulence, abdominal distention.
Drug Elimination:
Fecal.
Generic Drug Availability:
NO
How Supplied:
Caps—30
