Indications for: JANUVIA

Adjunct to diet and exercise in type 2 diabetes, as monotherapy or combination therapy.

Limitations of Use:

Not for treatment of type 1 diabetes. Not studied in patients with history of pancreatitis.

Adult Dosage:

100mg once daily. Renal impairment: eGFR ≥30–<45mL/min/1.73m2: 50mg once daily; eGFR <30mL/min/1.73m2 or ESRD on dialysis: 25mg once daily.

Children Dosage:

<18yrs: not established.

JANUVIA Warnings/Precautions:

Assess renal function before starting therapy and periodically thereafter. Consider risks/benefits in patients with known risk factors for heart failure; monitor for signs/symptoms; evaluate and consider discontinuing if develops. Monitor for pancreatitis, serious hypersensitivity reactions, severe joint pain, or bullous pemphigoid; discontinue if suspected or occurs. History of angioedema to other DPP-4 inhibitors. Severe hepatic impairment. Elderly. Pregnancy. Nursing mothers.

JANUVIA Classification:

Dipeptidyl peptidase-4 (DPP-4) inhibitor.

JANUVIA Interactions:

May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia.

Adverse Reactions:

Upper respiratory tract infection, nasopharyngitis, headache; pancreatitis, heart failure, hypersensitivity reactions (eg, anaphylaxis, angioedema, Stevens-Johnson syndrome), severe and disabling arthralgia, bullous pemphigoid.

Generic Drug Availability:


How Supplied:

Tabs 25mg, 50mg—30, 90, 100; 100mg—30, 90, 100, 1000