Colorectal disorders:

Indications for: IBSRELA

Irritable bowel syndrome with constipation (IBS-C).

Adult Dosage:

Take immediately prior to breakfast (or the first meal of the day) and prior to dinner. 50mg twice daily.

Children Dosage:

<18yrs: not established.

IBSRELA Contraindications:

Patients <6yrs of age. Known or suspected mechanical GI obstruction.

IBSRELA Warnings/Precautions:

Avoid use in patients 6–<12yrs of age. Suspend dosing and rehydrate if severe diarrhea occurs. Pregnancy. Nursing mothers.

IBSRELA Classification:

Sodium/hydrogen exchanger 3 (NHE3) inhibitor.

IBSRELA Interactions:

Antagonizes OATP2B1 substrates (eg, enalapril); monitor and increase dosage of substrates as needed.

Adverse Reactions:

Diarrhea, abdominal distension, flatulence, dizziness.

Generic Drug Availability:


How Supplied: