• Hypertension

Hypertension:

Indications for Hydralazine Injection:

Severe essential hypertension when oral therapy not feasible or there is an urgent need to lower blood pressure.

Adult:

Monitor BP closely. 20–40mg; repeat as needed. Advanced renal damage: reduce dose.

Children:

Not recommended; doses of 1.7–3.5mg/kg per day in 4–6 divided doses have been used.

Contraindications:

Coronary artery disease. Mitral valve disease.

Warnings/Precautions:

Suspected coronary artery disease. Cerebrovascular accidents. Aortic aneurysm. Increased intracranial pressure. Renal disease. Treat paresthesias and/or numbness with pyridoxine. Discontinue if blood dyscrasias occur. Obtain CBC and ANA titer periodically; consider discontinuing if SLE occurs. Surgery. Pregnancy (Cat.C). Nursing mothers.

Pharmacologic Class:

Vasodilator.

Interactions:

Caution with MAOIs. Profound hypotension with potent parenteral antihypertensives (eg, diazoxide). Antagonized by NSAIDs. May block epinephrine.

Adverse Reactions:

Headache, anorexia, GI disturbances, palpitations, edema, flushing, nasal congestion, lacrimation, rash, tachycardia, angina, orthostatic hypotension, blood dyscrasias, peripheral neuritis, SLE.

Note:

Formerly known under the brand names Apresoline (inj, tabs); Dralzine (tabs).

How Supplied:

Contact supplier.