Indications for: HUMALOG
Adults and Children:
<3yrs: not recommended. Onset ≤15mins, peak approx. 0.5–1.5hrs, duration approx. 3–5hrs. ≥3yrs: Give SC, either by injection or continuous infusion external pump. SC inj: give 15 mins before meal or immediately after a meal; use with an intermediate or long-acting insulin. Rotate inj sites. Continuous SC infusion pump: do not use diluted or mixed insulins in external pumps; change the Humalog in the reservoir at least every 7 days, change the infusion sets and insertion site at least every 3 days.
During episodes of hypoglycemia.
Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Do not reuse or share pens, needles, cartridges, or syringes between patients, even if the needle is changed. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia of hypoglycemia if changes in physical activity, meal patterns, concomitant medications, renal or hepatic function, insulin regimen, administration site, and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Hyperglycemia and ketoacidosis due to insulin pump device malfunction: see full labeling. Pregnancy. Nursing mothers.
Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by corticosteroids, isoniazid, niacin, danazol, diuretics, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, atypical antipsychotics. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. When mixing insulin lispro with other insulins, draw insulin lispro into syringe first and inject mixture immediately.
Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema.
Half-life: 51–55 minutes. Mean clearance: 21.0 mL/min/kg (for 0.1 U/kg); 9.6 mL/min/kg (for 0.2 U/kg).
Humalog Mix75/25, Humalog Mix50/50, Humalog vials (10mL)—1; Humalog Mix, Humalog U-100 KwikPen (prefilled) (3mL), Humalog U-100 Tempo Pen (prefilled) (3mL), Humalog U-100 Junior KwikPen (prefilled) (3mL), Humalog U-200 KwikPen (prefilled) (3mL)—5; Humalog cartridges (3mL)—5; HumaPen LUXURA HD (inj device, uses Humalog cartridges)—1