Nonnarcotic analgesics:
Indications for: HORIZANT
Postherpetic neuralgia.
Adult Dosage:
Swallow whole. Take with food. Initially 600mg in the AM for 3 days, then increase to 600mg twice daily beginning on Day 4 (no additional benefit seen with >1200mg daily dose). If dose is not taken at recommended time, skip this dose, and the next dose should be taken at the time of the next scheduled dose. Renal impairment: CrCl 30–59mL/min: initially 300mg in the AM for 3 days, then 300mg twice daily; may increase to 600mg twice daily if needed or tolerated. CrCl 15–29mL/min: 300mg in the AM on Day 1 and Day 3, then continue with 300mg in AM; may increase to 300mg twice daily if needed. CrCl <15mL/min: Maintenance: 300mg every other day in the AM, may increase to 300mg once daily if needed. CrCl <15mL/min on hemodialysis: Maintenance: 300mg after every session, may increase to 600mg if needed. Tapering doses: see full labeling.
Children Dosage:
Not studied.
HORIZANT Warnings/Precautions:
Not interchangeable with other gabapentin products. May cause significant driving impairment; do not drive until impairment is assessed. Epilepsy. Increased risk of suicidal thoughts/behavior. Monitor for new or worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Multiorgan hypersensitivity. Renal impairment. Avoid abrupt cessation (see full labeling). Elderly. Pregnancy. Nursing mothers.
HORIZANT Interactions:
Avoid alcohol. Increased somnolence/sedation with morphine. Increased risk for serious respiratory depression when concomitant CNS depressants, opioids.
Adverse Reactions:
Somnolence/sedation, dizziness, headache, nausea, dry mouth, fatigue, irritability, feeling drunk, vertigo.
Drug Elimination:
Renal (major), fecal.
How Supplied:
Tabs—30
Restless legs syndrome:
Indications for: HORIZANT
Treatment of moderate to severe primary restless legs syndrome. Not recommended for patients who are required to sleep during the daytime and remain awake at night.
Adult Dosage:
Swallow whole. Take with food. 600mg once daily at about 5pm (no additional benefit seen with 1200mg dose). If dose is not taken at recommended time, next dose should be taken the following day. Renal impairment: CrCl 30–59mL/min: initially 300mg/day and increase to 600mg as needed. CrCl 15–29mL/min: 300mg/day. CrCl <15mL/min: 300mg every other day. CrCl <15mL/min on hemodialysis: not recommended.
Children Dosage:
Not studied.
HORIZANT Warnings/Precautions:
Not interchangeable with other gabapentin products. May cause significant driving impairment; do not drive until impairment is assessed. Epilepsy. Increased risk of suicidal thoughts/behavior. Monitor for new or worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Multiorgan hypersensitivity. Renal impairment. Avoid abrupt cessation (see full labeling). Elderly. Pregnancy. Nursing mothers.
HORIZANT Interactions:
Avoid alcohol. Increased somnolence/sedation with morphine. Increased risk for serious respiratory depression when concomitant CNS depressants, opioids.
Adverse Reactions:
Somnolence/sedation, dizziness, headache, nausea, dry mouth, fatigue, irritability, feeling drunk, vertigo.
Drug Elimination:
Renal (major), fecal.
How Supplied:
Tabs—30
