CHF and arrhythmias:
Indications for Fosinopril:
Adjunct to diuretics in heart failure, with or without digitalis.
Adult:
Initially 10mg once daily. Moderate to severe renal failure or volume depleted: initially 5mg once daily. Maintenance: 20–40mg once daily.
Children:
Contact manufacturer.
Contraindications:
History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters).
Warnings/Precautions:
Salt/volume depletion. Renal or hepatic impairment. Monitor WBCs in renal or collagen vascular disease. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Monitor for hyperkalemia in diabetics. Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Surgery. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended.
Pharmacologic Class:
ACE inhibitor.
Interactions:
Potentiated by diuretics. Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements.
Adverse Reactions:
Angina, orthostatic hypotension, dizziness, cough, GI upset, pain, hyperkalemia, upper respiratory infection, arrhythmias, asthenia; angioneurotic edema (discontinue if occurs).
Note:
Formerly known under the brand name Monopril.
How Supplied:
Contact supplier.
Pricing for Fosinopril
Hypertension:
Indications for Fosinopril:
Hypertension.
Adult:
Initially 10mg once daily. Usual maintenance: 20–40mg daily in single or 2 divided doses; max 80mg/day. If on diuretic: suspend diuretic for 2–3 days before starting if possible; resume diuretic if pressure not controlled with fosinopril alone. If diuretic cannot be discontinued: give 10mg and monitor carefully.
Children:
<6yrs (≤50kg): not recommended. ≥6yrs (>50kg): 5–10mg once daily.
Contraindications:
History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters).
Warnings/Precautions:
Salt/volume depletion. Renal or hepatic impairment. Monitor WBCs in renal or collagen vascular disease. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Monitor for hyperkalemia in diabetics. Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Surgery. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended.
Pharmacologic Class:
ACE inhibitor.
Interactions:
Potentiated by diuretics. Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements.
Adverse Reactions:
Headache, cough, dizziness, GI upset, hyperkalemia, orthostatic hypotension, angioneurotic edema (discontinue if occurs).
Note:
Formerly known under the brand name Monopril.
How Supplied:
Contact supplier.
