Prostate and other male cancers:

Indications for Flutamide:

In combination with LHRH agonists (GnRH analogues) in locally confined stage B2–C and stage D2 metastatic prostate carcinoma.

Adult:

250mg every 8 hrs.

Children:

Not applicable.

Contraindications:

Severe hepatic impairment. ALT ≥2xULN: not recommended.

Warnings/Precautions:

Monitor liver function at baseline, monthly for first 4 months, then periodically, and if liver dysfunction occurs; if ALT >2xULN or jaundice occurs, discontinue and monitor closely until resolution. Monitor prostate specific antigen (PSA). Consider monitoring methemoglobin levels in patients susceptible to aniline toxicity (e.g., G6PD deficiency, smokers, hemoglobin M disease). Pregnancy (Cat.D); not for use in women.

Pharmacologic Class:

Antiandrogen.

Interactions:

Monitor warfarin.

Adverse Reactions:

Diarrhea, hot flashes, loss of libido, impotence, GI disturbances, gynecomastia, rash, edema, hypertension, CNS effects, blood dyscrasias, urine discoloration, liver failure.

Note:

Formerly known under the brand name Eulexin.

How Supplied:

Contact supplier.

Pricing for Flutamide

125mg capsule (Qty: 180)
Appx. price $116
GoodRx