Prostate and other male cancers:
Indications for: Flutamide
In combination with LHRH agonists (GnRH analogues) in locally confined stage B2–C and stage D2 metastatic prostate carcinoma.
Adult Dosage:
250mg every 8 hrs.
Children Dosage:
Not applicable.
Flutamide Contraindications:
Severe hepatic impairment. ALT ≥2xULN: not recommended.
Flutamide Warnings/Precautions:
Monitor liver function at baseline, monthly for first 4 months, then periodically, and if liver dysfunction occurs; if ALT >2xULN or jaundice occurs, discontinue and monitor closely until resolution. Monitor prostate specific antigen (PSA). Consider monitoring methemoglobin levels in patients susceptible to aniline toxicity (e.g., G6PD deficiency, smokers, hemoglobin M disease). Pregnancy (Cat.D); not for use in women.
Flutamide Classification:
Antiandrogen.
Flutamide Interactions:
Monitor warfarin.
Adverse Reactions:
Diarrhea, hot flashes, loss of libido, impotence, GI disturbances, gynecomastia, rash, edema, hypertension, CNS effects, blood dyscrasias, urine discoloration, liver failure.
Note:
Formerly known under the brand name Eulexin.
How Supplied:
Contact supplier.
