Prostate and other male cancers:

Indications for ERLEADA:

Metastatic castration-sensitive prostate cancer. Non-metastatic, castration-resistant prostate cancer.

Adult:

Swallow whole. Take with or without food. 240mg once daily. Give concurrent GnRH analog or patient should have had bilateral orchiectomy. Dose modification: see full labeling.

Children:

Not established.

Warnings/Precautions:

Monitor for signs/symptoms of ischemic heart disease; consider discontinuing if Grade 3/4 events occur. Manage CV risk factors (eg, hypertension, diabetes, dyslipidemia) optimally. Risk of seizures; permanently discontinue if occurs. Evaluate for fracture risk (monitor/manage based on guidelines; consider bone-targeted agents) and fall risk (esp. elderly). Embryo-fetal toxicity. Advise males (w. female partners of reproductive potential) to use effective contraception during and for 3 months after last dose.

Pharmacologic Class:

Androgen receptor inhibitor.

Interactions:

Potentiated by strong CYP2C8 or CYP3A4 inhibitors; reduce dose based on tolerability. Antagonizes drugs metabolized by CYP3A4, CYP2C19, or CYP2C9; use alternatives when possible. Caution with concomitant P-gp, BCRP, OATP1B1, or UGT substrates.

Adverse Reactions:

Fatigue, arthralgia, rash, decreased appetite, fall, weight decreased, hypertension, hot flush, diarrhea, fracture; ischemic CV events.

Generic Availability:

NO

How Supplied:

Tabs—120

Pricing for ERLEADA

60mg tablet (Qty: 120)
Appx. price $13715
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