Migraine and headache:

Indications for: Ergotamine tartrate + Caffeine Tablets

Migraine, migraine variants, cluster headaches.

Adult Dosage:

2 tablets at onset of attack, then 1 tablet every ½ hour if needed; max 6 tabs/attack, 10 tabs/week.

Children Dosage:

Not recommended.

Ergotamine tartrate + Caffeine Tablets Contraindications:

Peripheral vascular disease. Coronary heart disease. Hypertension. Hepatic or renal dysfunction. Sepsis. Concomitant potent CYP3A4 inhibitors (eg, ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) or other vasoconstrictors. Pregnancy. Labor and delivery.

Boxed Warning:

Peripheral ischemia following coadministration with strong CYP3A4 inhibitors.

Ergotamine tartrate + Caffeine Tablets Warnings/Precautions:

Monitor for ergotism; do not exceed recommended dose. Nursing mothers: not recommended.

Ergotamine tartrate + Caffeine Tablets Classification:

Ergot alkaloid.

Ergotamine tartrate + Caffeine Tablets Interactions:

See Contraindications. Potentiated by CYP3A4 inhibitors (eg, protease inhibitors, macrolides, azole antifungals, saquinavir, nefazodone, fluoxetine, fluvoxamine, grapefruit juice, zileuton), propranolol, nicotine. Severe hypertension with sympathomimetics.

Adverse Reactions:

Vasoconstrictive complications or ergotism (eg, ischemia, cold extremities, vasospasm, ECG changes, hyper- or hypotension, numbness, gangrene, dizziness), precordial or muscle pain, tachycardia, bradycardia, nausea, vomiting, local edema, itching; rarely: retroperitoneal and pleuropulmonary fibrosis, cardiac valve fibrosis (chronic use).


Formerly known under the brand names Cafergot, Migergot.



Drug Elimination:

Fecal (ergotamine), renal (caffeine). Half-life: 2 hours (ergotamine).

How Supplied:

Contact supplier.