Migraine and headache:

Indications for: Ergotamine tartrate + Caffeine Suppositories

Migraine, migraine variants, cluster headaches.

Adult Dosage:

1 supp rectally at onset of attack, then 1 supp after 1 hour if needed; max 2 supps/attack, 5 supps/week.

Children Dosage:

Not recommended.

Ergotamine tartrate + Caffeine Suppositories Contraindications:

Peripheral vascular disease. Coronary heart disease. Hypertension. Hepatic or renal dysfunction. Sepsis. Concomitant potent CYP3A4 inhibitors (eg, ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) or other vasoconstrictors. Pregnancy. Labor and delivery.

Boxed Warning:

Peripheral ischemia following coadministration with strong CYP3A4 inhibitors.

Ergotamine tartrate + Caffeine Suppositories Warnings/Precautions:

Monitor for ergotism; do not exceed recommended dose. Nursing mothers: not recommended.

Ergotamine tartrate + Caffeine Suppositories Classification:

Ergot alkaloid.

Ergotamine tartrate + Caffeine Suppositories Interactions:

See Contraindications. Potentiated by CYP3A4 inhibitors (eg, protease inhibitors, macrolides, azole antifungals, saquinavir, nefazodone, fluoxetine, fluvoxamine, grapefruit juice, zileuton), propranolol, nicotine. Severe hypertension with sympathomimetics.

Adverse Reactions:

Vasoconstrictive complications or ergotism (eg, ischemia, cold extremities, vasospasm, ECG changes, hyper- or hypotension, numbness, gangrene, dizziness), precordial or muscle pain, tachycardia, bradycardia, nausea, vomiting, local edema, itching; rarely: retroperitoneal and pleuropulmonary fibrosis, cardiac valve fibrosis (chronic use).


Formerly known under the brand names Cafergot, Migergot.



Drug Elimination:

Fecal (ergotamine), renal (caffeine). Half-life: 2 hours (ergotamine).

How Supplied:

Contact supplier.