Arthritis/rheumatic disorders:
Indications for: Diflunisal
Osteoarthritis. Rheumatoid arthritis.
Adult Dosage:
250–500mg twice daily; max 1.5g/day.
Children Dosage:
Not recommended.
Diflunisal Contraindications:
Aspirin allergy. Varicella or influenza in teenagers. 3rd trimester pregnancy. Coronary artery bypass graft surgery.
Diflunisal Warnings/Precautions:
Advanced renal disease: not recommended. Active peptic ulcer or GI bleeding. History of GI disease. Cardiac failure. Hypertension. Impaired renal or hepatic function. Volume depletion. Bleeding disorders. Sepsis. Diabetes. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C in 1st and 2nd trimesters). Nursing mothers: not recommended.
Diflunisal Classification:
Salicylate.
Diflunisal Interactions:
Avoid methotrexate, indomethacin. Oral anticoagulants potentiated. Increased acetaminophen and hydrochlorothiazide serum levels. Reduced absorption with antacids.
Adverse Reactions:
Peptic ulcer, GI bleeding, nausea, dyspepsia, GI pain, diarrhea, rash (discontinue if occurs), headache, dizziness, edema, nephritis. See literature re: risk of cardiovascular disease.
Note:
Formerly known under the brand name Dolobid.
How Supplied:
Contact supplier.
Nonnarcotic analgesics:
Indications for: Diflunisal
Mild to moderate pain.
Adult Dosage:
0.5–1g once then 250–500mg every 8–12 hrs.
Children Dosage:
Not recommended.
Diflunisal Contraindications:
Aspirin allergy. Varicella or influenza in teenagers. 3rd trimester pregnancy. Coronary artery bypass graft surgery.
Diflunisal Warnings/Precautions:
Advanced renal disease: not recommended. Active peptic ulcer or GI bleeding. History of GI disease. Cardiac failure. Hypertension. Impaired renal or hepatic function. Volume depletion. Bleeding disorders. Sepsis. Diabetes. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C in 1st and 2nd trimesters). Nursing mothers: not recommended.
Diflunisal Classification:
Salicylate.
Diflunisal Interactions:
Avoid methotrexate, indomethacin. Oral anticoagulants potentiated. Increased acetaminophen and hydrochlorothiazide serum levels. Reduced absorption with antacids.
Adverse Reactions:
Peptic ulcer, GI bleeding, nausea, dyspepsia, GI pain, diarrhea, rash (discontinue if occurs), headache, dizziness, edema, nephritis. See literature re: risk of cardiovascular disease.
Note:
Formerly known under the brand name Dolobid.
How Supplied:
Contact supplier.
