Leukemias, lymphomas, and other hematologic cancers:
Indications for: DEPOCYT
Intrathecal treatment of lymphomatous meningitis.
Adult Dosage:
See full labeling. Give intrathecally over 1–5 minutes. Administer dexamethasone 4mg twice daily for 5 days with each cycle of treatment. Induction: 50mg every 14 days for 2 doses (weeks 1 and 3). Consolidation: 50mg every 14 days for 3 doses (weeks 5, 7 and 9) followed by 1 additional dose at week 13. Maintenance: 50mg every 28 days for 4 doses (weeks 17, 21, 25 and 29). Reduce dose to 25mg if neurotoxicity develops and discontinue if it persists.
Children Dosage:
Not recommended.
DEPOCYT Contraindications:
Active meningeal infection.
DEPOCYT Warnings/Precautions:
Chemical arachnoiditis; reduce symptoms with dexamethasone. Previous irradiation, cytotoxic chemotherapy. Monitor blood counts and for development of neurotoxicity. Renal and hepatic impairment. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
DEPOCYT Classification:
Antimetabolite.
DEPOCYT Interactions:
Increased risk of neurotoxicity with concomitant cranial/spinal irradiation or other intrathecal antineoplastics.
Adverse Reactions:
See full labeling. Arachnoiditis, GI upset, headache, fever, neurological toxicity (myelopathy), hydrocephalus, elevated CSF protein and WBC, weakness, back pain, insomnia, blurred vision, anaphylactic reactions; others.
How Supplied:
Single-use vials (5mL)—1
