Gout:

Indications for: COLCRYS

Prophylaxis and treatment of acute gout flares. Familial Mediterranean fever (FMF).

Adult Dosage:

Gout prophylaxis: >16yrs: 0.6mg once or twice daily; max 1.2mg/day. Gout treatment: 1.2mg at first sign of gout flare, then 0.6mg 1 hour later; max 1.8mg over a 1 hour period; may be given during prophylaxis at max 1.2mg at first sign of flare, then 0.6mg 1 hour later, wait 12 hours, then resume prophylactic dose. FMF: Usual range: 1.2mg–2.4mg daily; may give in 1–2 divided doses. May increase/decrease dose (depending on tolerability) in increments of 0.3mg/day to max daily dose. For all: concomitant CYP3A4 and/or P-glycoprotein inhibitors, severe renal or hepatic impairment: reduce dose (see full labeling).

Children Dosage:

FMF: <4yrs: not recommended. Give as a single or divided dose twice daily. 4–6yrs: 0.3mg–1.8mg daily; 6–12yrs: 0.9mg–1.8mg daily. May increase/decrease dose (depending on tolerability) in increments of 0.3mg/day to max daily dose. Concomitant CYP3A4 and/or P-glycoprotein inhibitors, severe renal or hepatic impairment: reduce dose (see full labeling).

COLCRYS Contraindications:

Renal or hepatic impairment with concomitant P-glycoprotein or strong CYP3A4 inhibitors (includes all protease inhibitors except fosamprenavir); life-threatening toxicity possible.

COLCRYS Warnings/Precautions:

Monitor for toxicity; if present, consider temporary interruption or discontinuation. Renal or hepatic impairment. Elderly. Pregnancy. Nursing mothers.

COLCRYS Classification:

Antiinflammatory.

COLCRYS Interactions:

See Contraindications. Potentiated by concomitant CYP3A4 inhibitors (eg, atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, grapefruit juice) and/or P-glycoprotein inhibitors (eg, cyclosporine, ranolazine). Concomitant statins, gemfibrozil, fibrates, digoxin may potentiate myopathy and rhabdomyolysis.

Adverse Reactions:

GI upset, abdominal pain, pharyngolaryngeal pain; blood dyscrasias, neuromuscular toxicity, rhabdomyolysis, overdosage (may be fatal).

Metabolism:

Hepatic.

Drug Elimination:

Renal. Half-life: 26.6–31.2 hours.

Generic Drug Availability:

YES

How Supplied:

Tabs—30, 60, 100, 1000