Hereditary angioedema:

Indications for: CINRYZE

Routine prophylaxis against angioedema attacks in patients ≥6yrs with hereditary angioedema (HAE).

Adult Dosage:

Give by IV infusion at a rate of 1mL/min (10mins). ≥12yrs: 1000 Units every 3–4 days. May consider doses up to 2500 Units (max 100 Units/kg) every 3–4 days if inadequate response.

Children Dosage:

<6yrs: not established. Give by IV infusion at a rate of 1mL/min (5mins). 6–11yrs: 500 Units every 3–4 days. May adjust dose up to 1000 Units every 3–4 days based on response.

CINRYZE Warnings/Precautions:

Contains human plasma; monitor for possible infection transmission (eg, viruses, Creutzfeldt-Jakob disease agent). Have epinephrine available to treat hypersensitivity reactions. Monitor patients with known risk factors for thrombotic events. Pregnancy. Nursing mothers.

CINRYZE Classification:

C1 inhibitor.

Adverse Reactions:

Headache, nausea, rash, vomiting, fever; thrombotic events, hypersensitivity reactions (may be severe; discontinue if occur).


To report infections that may have been transmitted by Cinryze, call CinryzeSolutions at (877) 945-1000.

Generic Drug Availability:


How Supplied:

Single-use vial—1