Edema:
Indications for: Chlorthalidone
Edema.
Adult Dosage:
Initially 50–100mg daily or 100mg on alternate days. Some may require 150–200mg at these intervals or up to 200mg daily. Maintenance: doses often lower than initial doses; individualize.
Children Dosage:
Not established.
Chlorthalidone Contraindications:
Anuria. Sulfonamide allergy.
Chlorthalidone Warnings/Precautions:
Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Volume depletion. Salt restriction. Monitor electrolytes; discontinue if electrolyte abnormalities develop. Metabolic disturbances. Pregnancy. Nursing mothers: not recommended.
Chlorthalidone Classification:
Diuretic (monosulfamyl).
Chlorthalidone Interactions:
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.
Adverse Reactions:
Electrolyte abnormalities (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).
Note:
Formerly known under the brand name Hygroton.
How Supplied:
Contact supplier.
Hypertension:
Indications for: Chlorthalidone
Hypertension.
Adult Dosage:
Initially 25mg once daily; if needed may increase to 50mg once daily. If additional control needed, increase to 100mg once daily or add second antihypertensive. Maintenance: doses should be lower than initial doses; individualize.
Children Dosage:
Not established.
Chlorthalidone Contraindications:
Anuria. Sulfonamide allergy.
Chlorthalidone Warnings/Precautions:
Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Volume depletion. Salt restriction. Monitor electrolytes; discontinue if electrolyte abnormalities develop. Metabolic disturbances. Pregnancy. Nursing mothers: not recommended.
Chlorthalidone Classification:
Diuretic (monosulfamyl).
Chlorthalidone Interactions:
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.
Adverse Reactions:
Electrolyte abnormalities (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).
Note:
Formerly known under the brand name Hygroton.
How Supplied:
Contact supplier.
