Indications for: Chlorpropamide

Adjunct to diet in type 2 diabetes.

Adult Dosage:

Initially 250mg daily. Elderly: initially 100–125mg daily. Titrate dose. Take with breakfast. Max 750mg daily.

Children Dosage:

Not recommended.

Chlorpropamide Contraindications:

Type 1 diabetes mellitus. Diabetic ketoacidosis.

Chlorpropamide Warnings/Precautions:

Oral hypoglycemic agents may increase risk of cardiovascular mortality. Impaired renal or hepatic function. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. G6PD deficiency. Monitor urine and blood glucose. Discontinue if jaundice or persistent rash occurs. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider insulin instead. Nursing mothers: not recommended.

Chlorpropamide Classification:

Sulfonylurea (1st generation).

Chlorpropamide Interactions:

Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers. Antagonized by diuretics, steroids, phenothiazines, thyroid products, phenytoin, niacin, sympathomimetics, calcium channel blockers and isoniazid. Disulfiram-like reaction with alcohol.

Adverse Reactions:

Hypoglycemia, cholestatic jaundice, GI disturbances, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria.


Formerly known under the brand name Diabinese.

How Supplied:

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