Angina:
Indications for CARDIZEM CD:
Vasospastic and chronic stable angina.
Adult:
Initially 120–180mg once daily. Titrate over 7–14 days; usual max 480mg once daily. Concomitant simvastatin: max 240mg/day.
Children:
Not established.
Contraindications:
Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.
Warnings/Precautions:
CHF. Renal or hepatic impairment (monitor). Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
See Also:
Pharmacologic Class:
Calcium channel blocker (CCB) (benzothiazepine).
Interactions:
Concomitant ivabradine, rifampin, alcohol: avoid. Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, quinidine, lovastatin, simvastatin (limit to max 10mg/day); monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers. Anesthetics may potentiate cardiac depression.
Adverse Reactions:
Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, rash (may be serious); rare: hypotension, liver abnormalities.
How Supplied:
LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90; Tabs 30mg—100, 500; 60mg, 90mg, 120mg—100
Pricing for CARDIZEM CD
Hypertension:
Indications for CARDIZEM CD:
Hypertension.
Adult:
Initially 180–240mg once daily; adjust at 2-week intervals. Usual range: 240–360mg once daily; usual max 480mg once daily. Concomitant simvastatin: max 240mg/day.
Children:
Not established.
Contraindications:
Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.
Warnings/Precautions:
CHF. Renal or hepatic impairment (monitor). Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
See Also:
Pharmacologic Class:
Calcium channel blocker (CCB) (benzothiazepine).
Interactions:
Concomitant ivabradine, rifampin, alcohol: avoid. Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, quinidine, lovastatin, simvastatin (limit to max 10mg/day); monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers. Anesthetics may potentiate cardiac depression.
Adverse Reactions:
Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, rash (may be serious); rare: hypotension, liver abnormalities.
How Supplied:
LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90
