BABYBIG Rx

Have epinephrine available. Do not exceed recommended infusion rate. Monitor for infusion reactions; slow infusion rate or interrupt if occur; discontinue if anaphylaxis or hypotension occurs. Ensure adequate hydration. Pre-existing renal insufficiency or risk of (eg, diabetes mellitus, volume depletion, paraproteinemia, sepsis, taking nephrotoxic drugs); infuse at minimum concentration and rate practicable; monitor. Assess renal function, urine output, BUN, serum creatinine, prior to initial infusion and periodically thereafter; consider discontinuing if renal function deteriorates. Increased thrombosis risk in history of atherosclerosis, multiple CV risk factors, advanced age, impaired cardiac output, coagulation disorders, prolonged immobilization, and/or known or suspected hyperviscosity; infuse at minimum rate practicable; monitor. Consider baseline assessment of blood viscosity in those at risk of hyperviscosity, including cryoglobulins, chylomicronemia, markedly high triglycerides, or monoclonal gammopathies. Monitor for hemolysis. Perform neurological exam if signs/symptoms of aseptic meningitis syndrome develop (including CSF studies). Monitor for pulmonary adverse reactions; if transfusion-related acute lung injury (TRALI) suspected, perform appropriate tests. Contains human plasma; monitor for possible infection transmission (eg, viruses, Creutzfeldt-Jakob disease agent).