Bacterial infections:
Indications for: AVYCAZ
Susceptible infections including complicated intra-abdominal infections (cIAI), in combination with metronidazole, complicated urinary tract infections (cUTI), including pyelonephritis, and hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP).
Adult Dosage:
Give by IV infusion over 2hrs. ≥18yrs: 2.5g every 8hrs. cIAI (in combination with metronidazole): treat for 5–14 days. cUTI, HABP/VABP: treat for 7–14 days. Renal impairment (CrCl 31–50mL/min): 1.25g every 8hrs; (CrCl 16–30mL/min): 0.94g every 12hrs; (CrCl 6–15mL/min): 0.94g every 24hrs; (CrCl ≤5mL/min): 0.94g every 48hrs; give after hemodialysis on hemodialysis days.
Children Dosage:
<3mos: not established. Give by IV infusion over 2hrs. 3mos–<6mos: 50mg/kg every 8hrs; 6mos–<2yrs: 62.5mg/kg every 8hrs; 2–<18yrs: 62.5mg/kg up to max 2.5g every 8hrs. cIAI (in combination with metronidazole): treat for 5–14 days. cUTI, HABP/VABP: treat for 7–14 days. Renal impairment: ≥2yrs: (CrCl 31–50mL/min): 31.25mg/kg up to max 1.25g every 8hrs; (CrCl 16–30mL/min): 23.75mg/kg up to max 0.94g every 12hrs; (CrCl 6–15mL/min): 23.75mg/kg up to max 0.94g every 24hrs; (CrCl ≤5mL/min): 23.75mg/kg up to max 0.94g every 48hrs; give after hemodialysis on hemodialysis days.
AVYCAZ Contraindications:
Cephalosporin hypersensitivity.
AVYCAZ Warnings/Precautions:
Penicillin or other beta-lactam allergy. Discontinue if allergic reaction occurs. Evaluate and manage fluid, electrolyte levels, supplement protein intake if C.diff-associated diarrhea suspected or confirmed. Renal impairment; monitor CrCl at least daily and adjust dose as necessary. Pregnancy. Nursing mothers.
AVYCAZ Classification:
Cephalosporin + beta-lactamase inhibitor.
AVYCAZ Interactions:
Concomitant probenecid: not recommended. False (+) urine glucose test possible.
Adverse Reactions:
Diarrhea, nausea, vomiting; C.diff-associated diarrhea, hypersensitivity reactions, CNS reactions (eg, seizure, encephalopathy, coma). Children: also rash, infusion site phlebitis.
Drug Elimination:
Renal. Half-life: 3.27 hours (ceftazidime), 2.22 hours (avibactam).
Generic Drug Availability:
NO
How Supplied:
Single-use vial—1, 10
