Miscellaneous dermatological conditions:
Indications for: ASCLERA
To sclerose uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1–3mm in diameter) in the lower extremity.
Adult Dosage:
For IV use only. Spider veins: use 0.5%. Reticular veins: use 1%. Inject soln slowly. Give 0.1–0.3mL per inj; max: 10mL per treatment session. Repeat if necessary; separate sessions by 1–2 weeks. Cover inj site; apply compression bandage or stocking. Have patient walk for 15–20mins after treatment; monitor. Maintain compression (spider veins): 2–3 days; (reticular veins): 5–7 days.
Children Dosage:
Not established.
ASCLERA Contraindications:
Acute thromboembolic diseases.
ASCLERA Warnings/Precautions:
Not studied in varicose veins >3mm in diameter. Do not inject intra-arterially. Monitor for 15–20mins post-inj for anaphylaxis; treat appropriately if occurs. Monitor for venous thrombosis posttreatment. Increased risk of thrombosis in patients with reduced mobility, history of DVT/PE, pregnancy, major surgery within 3mos, prolonged hospitalization. Arterial embolism. Avoid polidocanol foamed with room air. Advise to avoid heavy exercise, sunbathing, long plane flights, hot baths/sauna 2–3 days posttreatment. Pregnancy. Nursing mothers: consider interrupting breastfeeding up to 8hrs after dose.
ASCLERA Classification:
Sclerosing agent.
Adverse Reactions:
Mild local reactions at inj site; anaphylaxis (may be fatal).
Generic Drug Availability:
NO
How Supplied:
Single-use ampules (2mL)—5
