Bacterial infections:
Indications for: ANTHIM
Treatment of inhalational anthrax in combination with appropriate antibacterial drugs. Prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.
Limitations of Use:
Only use for prophylaxis when its benefit of anthrax prevention outweighs risk of hypersensitivity and anaphylaxis. Has no direct antibacterial activity. Does not cross the blood-brain barrier. Does not prevent or treat meningitis. Pediatrics: safety and pharmacokinetics were not studied.
Adult Dosage:
See full labeling. Premedicate with diphenhydramine prior to infusion. Give as IV infusion over 90mins. >40kg: 16mg/kg.
Children Dosage:
See full labeling. Premedicate with diphenhydramine prior to infusion. Give as IV infusion over 90mins. ≤15kg: 32mg/kg; >15–40kg: 24mg/kg; >40kg: use adult dose.
Boxed Warning:
Hypersensitivity. Anaphylaxis.
ANTHIM Warnings/Precautions:
Have trained personnel and medical equipment readily available. Monitor infusion during and after administration. Discontinue immediately and treat if anaphylaxis or hypersensitivity reactions occur. Pregnancy. Nursing mothers.
ANTHIM Classification:
Monoclonal antibody.
Adverse Reactions:
Headache, pruritus, infections of the upper respiratory tract, cough, vessel puncture site bruise, infusion site swelling, nasal congestion, infusion site pain, urticaria, pain in extremity.
Generic Drug Availability:
NO
How Supplied:
Single-dose vial (6mL)—1
