Edema:
Indications for: Amiloride
Adjunct in edema where normokalemia is important.
Adult Dosage:
Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring. After initial diuresis, reassess therapy; may be given intermittently for maintenance.
Children Dosage:
Not established.
Amiloride Contraindications:
Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy.
Amiloride Warnings/Precautions:
Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Amiloride Classification:
Diuretic (K+ sparing).
Amiloride Interactions:
Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test.
Adverse Reactions:
Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence.
Note:
Formerly known under the brand name Midamor.
How Supplied:
Contact supplier
Hypertension:
Indications for: Amiloride
Adjunct in hypertension.
Adult Dosage:
Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring.
Children Dosage:
Not established.
Amiloride Contraindications:
Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy.
Amiloride Warnings/Precautions:
Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Amiloride Classification:
Diuretic (K+ sparing).
Amiloride Interactions:
Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test.
Adverse Reactions:
Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence.
Note:
Formerly known under the brand name Midamor.
How Supplied:
Contact supplier
