Migraine and headache:

Indications for: AMERGE

Acute treatment of migraine with or without aura. 

Limitations of Use:

Use only after a clear diagnosis of migraine has been established. Not indicated for the prevention of migraine attacks. Safety and effectiveness of Amerge have not been established for cluster headache.

Adult Dosage:

≥18yrs: 1mg or 2.5mg with fluids; may repeat once after 4hrs; max 5mg/24hrs. The safety of treating, on average, more than 4 headaches in a 30-day period has not been established. Mild to moderate renal or hepatic impairment: initially 1mg; max 2.5mg/24hrs.

Children Dosage:

<18yrs: not recommended.

AMERGE Contraindications:

Ischemic coronary artery disease (angina pectoris, history of MI, or documented silent ischemia) or vasospasm, including Prinzmetal's angina. Wolff-Parkinson-White syndrome. Arrhythmias associated with other cardiac accessory conduction pathway disorders. History of stroke, TIA, or basilar or hemiplegic migraine. Peripheral vascular disease. Ischemic bowel disease. Uncontrolled hypertension. Within 24hrs of other 5-HT1 agonists or ergot-type drugs. Severe renal or hepatic impairment.

AMERGE Warnings/Precautions:

Confirm diagnosis. Exclude underlying cardiovascular disease, supervise 1st dose, and consider monitoring ECG in patients with likelihood of unrecognized coronary disease (eg, increased age, hypertension, obesity, diabetes, smokers, strong family history). Monitor cardiovascular function in long-term intermittent use. Discontinue if arrhythmias, cerebrovascular events, or serotonin syndrome occur. Possible peripheral or GI vascular ischemia, splenic infarction, or Raynaud's syndrome following use of 5-HT1 agonists. Monitor BP during treatment. Hepatic or renal dysfunction. Elderly (monitor). Pregnancy. Nursing mothers.

AMERGE Classification:

Selective 5-HT1B/1D receptor agonist.

AMERGE Interactions:

Methysergide, other ergotamines, or other 5-HT1 agonists: see Contraindications. Serotonin syndrome with SSRIs, SNRIs, TCAs, or MAOIs.

Adverse Reactions:

Paresthesias, nausea, dizziness, drowsiness, malaise/fatigue, throat/neck symptoms (pain, pressure, tightness), drug overuse headache (discontinue if occurs); rare: serious cardiac events, anaphylactoid reactions.


Register pregnant patients exposed to naratriptan by calling (800) 336-2176.

Generic Drug Availability:


How Supplied: