Sleep-wake disorders:

Indications for AMBIEN CR:



Swallow whole. Use lowest effective dose. Initially 6.25mg (in women), and 6.25mg or 12.5mg (in men) at bedtime (take only if able to get 7–8hrs of sleep before becoming active again). Both: if 6.25mg dose ineffective, may increase to max 12.5mg. Elderly, debilitated, or mild-to-moderate hepatic impairment: 6.25mg once daily at bedtime. Effect delayed if taken with a meal.


<18yrs: not recommended.


Risk of CNS depressant effects and next-day impairment. Evaluate for co-morbid diagnoses before initiation. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Abnormal thinking and behavioral changes. Compromised respiratory function. Sleep apnea. Myasthenia gravis. Avoid in severe hepatic impairment; may contribute to encephalopathy. Drug or alcohol abuse. Write ℞ for smallest practical amount. Withdraw gradually. Elderly (higher risk of falls). Debilitated. Labor & delivery. Neonates. Pregnancy. Nursing mothers: monitor infants; may consider pumping/discarding breast milk during and for 23hrs after administration.

See Also:

Pharmacologic Class:

Imidazopyridine hypnotic.


Concomitant other sedative-hypnotics including other zolpidem products: not recommended. Increased risk of CNS depression, drowsiness, psychomotor impairment with alcohol, other CNS depressants (eg, benzodiazepines, opioids, tricyclics). May be potentiated by CYP3A4 inhibitors (eg, ketoconazole), sertraline; use lower zolpidem dose. Decreased alertness with imipramine, chlorpromazine. May be antagonized by CYP3A4 inducers (eg, rifampin, St. John's wort); avoid concomitant use.

Adverse Reactions:

Headache, next-day somnolence, drowsiness, dizziness, diarrhea, dry mouth; CNS effects, complex behaviors (eg, sleep-driving), anaphylaxis, angioedema.

How Supplied:

CR tabs—100; tabs—100

Pricing for AMBIEN CR

12.5mg tablet (Qty: 30)
Appx. price $34