CHF and arrhythmias:
Indications for: Acebutolol
Ventricular arrhythmias.
Adult Dosage:
Initially 200mg twice a day. Usual range: 600mg–1.2g daily.
Children Dosage:
Not established.
Acebutolol Contraindications:
Severe bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Acebutolol Warnings/Precautions:
Bronchospastic disease. Ischemic heart disease or failure. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Vascular insufficiency. Surgery. Avoid abrupt cessation. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Acebutolol Classification:
Cardioselective beta-blocker.
Acebutolol Interactions:
May potentiate hypotension with prazosin, reserpine, other catecholamine-depleting drugs. Antagonized by NSAIDs. May increase cardiac effects of verapamil, digitalis. Avoid α-adrenergic agonists. May block epinephrine.
Adverse Reactions:
Fatigue, dizziness, headache, GI upset, dyspnea, dysuria, insomnia, rash, myalgia, rhinitis, abnormal vision, hypotension, bradycardia, heart failure or block, bronchospasm, elevated ANA titers.
Note:
Formerly known under the brand name Sectral.
Drug Elimination:
The plasma elimination half-life of acebutolol is approximately 3 to 4 hours, while that of its metabolite, diacetolol, is 8 to 13 hours. Elimination via renal excretion is approximately 30% to 40% and by nonrenal mechanisms 50% to 60%, which includes excretion into the bile and direct passage through the intestinal wall.
How Supplied:
Contact supplier
Hypertension:
Indications for: Acebutolol
Hypertension.
Adult Dosage:
Initially 400mg daily in 1–2 divided doses. Usual range: 200–800mg daily; max 1.2g/day in 2 divided doses.
Children Dosage:
Not established.
Acebutolol Contraindications:
Severe bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Acebutolol Warnings/Precautions:
Bronchospastic disease. Ischemic heart disease or failure. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Vascular insufficiency. Surgery. Avoid abrupt cessation. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Acebutolol Classification:
Cardioselective beta-blocker.
Acebutolol Interactions:
May potentiate hypotension with prazosin, reserpine, other catecholamine-depleting drugs. Antagonized by NSAIDs. May increase cardiac effects of verapamil, digitalis. Avoid α-adrenergic agonists. May block epinephrine.
Adverse Reactions:
Fatigue, dizziness, headache, GI upset, dyspnea, dysuria, insomnia, rash, myalgia, rhinitis, abnormal vision, hypotension, bradycardia, heart failure or block, bronchospasm, elevated ANA titers.
Note:
Formerly known under the brand name Sectral.
Drug Elimination:
The plasma elimination half-life of acebutolol is approximately 3 to 4 hours, while that of its metabolite, diacetolol, is 8 to 13 hours. Elimination via renal excretion is approximately 30% to 40% and by nonrenal mechanisms 50% to 60%, which includes excretion into the bile and direct passage through the intestinal wall.
How Supplied:
Contact supplier