Diabetic Nephropathy

SGLT2 Inhibitors May Reduce CV, Renal Risks in Type 2 Diabetes

SGLT2 Inhibitors May Reduce CV, Renal Risks in Type 2 Diabetes

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SGLT2i reduced the risks for progression of renal disease by 45% and heart failure hospitalization by 31% in patients with type 2 diabetes.

Bardoxolone Methyl Leads to Weight Loss in T2D With Concurrent Chronic Kidney Disease

Bardoxolone Methyl Leads to Weight Loss in T2D With Concurrent Chronic Kidney Disease

Treatment with bardoxolone methyl resulted in significant weight loss and showed no evidence of muscle wasting in patients with type 2 diabetes and stage IV chronic kidney disease.

Aggressive Control of BP, Lipids in T2DM May Up Kidney Risk

Aggressive Control of BP, Lipids in T2DM May Up Kidney Risk

Strict BP control, fenofibrate use may increase long-term risk for adverse kidney events in T2DM patients

ADA, EASD Issue New Recommendations for T2DM

ADA, EASD Issue New Recommendations for T2DM

Additional focus on lifestyle management, self-management education and support emphasized

Metformin Can Be Used Safely at Lower Levels of Renal Function

Metformin Can Be Used Safely at Lower Levels of Renal Function

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New study shows metformin is not associated with an increased risk of acidosis in patients with type 2 diabetes and an eGFR of 30 to 60 mL/min/1.73 m2.

Study: ESRD Risk in Type 1 Diabetes Pts Has Declined

Study: ESRD Risk in Type 1 Diabetes Pts Has Declined

Relative risk of end-stage renal disease was 0.13 in those diagnosed in 1995-2011 versus 1965-1979.

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

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Liraglutide-treated patients were 22% less likely than placebo recipients to experience a composite outcome of renal events.

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

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Use of the glucagon-like peptide-1 receptor agonist lowered 24-hour urinary albumin excretion rate by 32% over 12 weeks versus placebo.

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Findings in large cohort of patients with diabetes over 4 years of follow-up.

Advanced Glycation End-Products Predict Renal Function Decline

Advanced Glycation End-Products Predict Renal Function Decline

AGEs improve RFL prediction in American-Indians with type 2 diabetes.

Diabetic Kidney Disease Rates in US Hold Steady

Diabetic Kidney Disease Rates in US Hold Steady

No change in overall prevalence from 1988 to 2014; decrease in albuminuria, increase in reduced eGFR.

Slower Kidney Disease Progression Observed With Empagliflozin Use

Slower Kidney Disease Progression Observed With Empagliflozin Use

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Incident or worsening nephropathy was observed in 12.7% of patients receiving empagliflozin compared with 18.8% of those receiving placebo.

Diabetes Remission From Surgery Cuts Microvascular Disease Risk

Diabetes Remission From Surgery Cuts Microvascular Disease Risk

Length of time spent in remission inversely related to risk of microvascular disease.

Kidney Function Decline Tied to CV Events in Diabetics

Kidney Function Decline Tied to CV Events in Diabetics

Renal function decline is independent factor for cardiovascular risk in patients with type 2 diabetes.

Study: Diabetic Nephropathy Underdiagnosed

Study: Diabetic Nephropathy Underdiagnosed

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Diabetic nephropathy lesions may develop prior to the onset of clinical findings.

Diabetes, Diabetic Nephropathy Increased in Children

Diabetes, Diabetic Nephropathy Increased in Children

Increase in prevalence from 2002-2013, with highest prevalence among those aged 12 to less than 18 years.

Urinary Potassium Linked to Lower ESRD, CVD Risk in Diabetes

Urinary Potassium Linked to Lower ESRD, CVD Risk in Diabetes

Higher urinary potassium excretion, not sodium excretion, tied to lower risk of primary end point.

Renal Biomarkers Predict Diabetes Outcomes

Renal Biomarkers Predict Diabetes Outcomes

AKI, albuminuria, eGFR considered separately or together can predict adverse outcomes in diabetes.

Nonalbuminuric CKD May Increase Mortality in Type 1 Diabetes

Nonalbuminuric CKD May Increase Mortality in Type 1 Diabetes

Nonalbuminuric chronic kidney disease was linked to increases in all-cause and cardiovascular mortality, but not albuminuria or end-stage renal disease.

Poorly Controlled Diabetes May Increase Dementia

Poorly Controlled Diabetes May Increase Dementia

Older patients with more diabetes complications have greater cognitive decline, study finds.

Diabetic Kidney Disease Linked to High Uric Acid

Diabetic Kidney Disease Linked to High Uric Acid

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Increased uric acid levels were correlated with decreased HbA1c and increased prevalence of diabetic kidney disease, study finds.

Mild CKD and Tight Glucose Control Increase Risks in Diabetics

Mild CKD and Tight Glucose Control Increase Risks in Diabetics

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Intense glycemic control was significantly linked to higher risks of cardiovascular and all-cause mortality

Women with Type 1 Diabetes Fare Worse Than Men

Women with Type 1 Diabetes Fare Worse Than Men

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Among the increased risks, women with the disease had an 86% higher chance of dying from cardiovascular disease than men.

Diabetic Nephropathy More Common Than Previously Thought

Diabetic Nephropathy More Common Than Previously Thought

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Researchers in the Netherlands report results from an autopsy study of diabetic nephropathy patients.

Diabetic Nephropathy Linked to Hypothyroidism

Diabetic Nephropathy Linked to Hypothyroidism

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Researchers find an independent association in a study of Japanese patients with type 2 diabetes.

Fewer Ophthalmologists Linked to Poorer Retinopathy Treatment

Fewer Ophthalmologists Linked to Poorer Retinopathy Treatment

Public health efforts needed to ensure adequate access to ophthalmologists.

Abatacept May Prevent Kidney Disease Advance in Diabetics

Abatacept May Prevent Kidney Disease Advance in Diabetics

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The drug maintained kidney function in mice with diabetic nephropathy.

Gluten-Free Diet Helps to Prevent Diabetic Nephropathy

Gluten-Free Diet Helps to Prevent Diabetic Nephropathy

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A trial of a gluten-free diet presents no inherent risk for patients starting to exhibit microvascular damage.

Diabetes-Related ESRD Risk Higher Among Indigenous Canadians

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Among Canadian diabetics, end-stage renal disease is almost three times more likely to development among First Nation adults.

Diabetic Nephropathy Not Improved by Dual Regimen

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ACE inhibitor plus ARB failed to slow disease progression but increased acute kidney injury risk.

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