Diabetic Nephropathy News Archive

Biomarkers Predict Rapid Renal Decline in Type 2 Diabetes

Biomarkers Predict Rapid Renal Decline in Type 2 Diabetes

Biomarkers apoA4, CD5L, C1QB, and IBP3 may improve the prediction of rapid decline in renal function independently of recognized clinical risk factors in T2DM.

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide-treated patients were 22% less likely than placebo recipients to experience a composite outcome of renal events.

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Almost 40% of pre-dialysis patients with stage 4-5 CKD patients and type 2 diabetes had lab results suggesting low turnover bone disease.

Low Tryptophan May Signal Diabetic Nephropathy

Low Tryptophan May Signal Diabetic Nephropathy

There was a significant association for Trp with the event of rapid decline in eGFR.

sRAGE May Increase Risk of Diabetic Nephropathy

sRAGE May Increase Risk of Diabetic Nephropathy

Higher levels of sRAGE were significantly associated with incidence of DN after adjustment for duration of diabetes.

Children With Diabetic Ketoacidosis at High Risk of AKI

Children With Diabetic Ketoacidosis at High Risk of AKI

Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.

Increased Use of DPP-4, SGLT-2 Inhibitors for Diabetic Nephropathy

Increased Use of DPP-4, SGLT-2 Inhibitors for Diabetic Nephropathy

DPP-4 inhibitors use was used in 54% of treatment visits by the last quarter of 2014; ACEIs and ARBs were prescribed in the majority of treatment visits with peaks above 90%.

Valsartan Reduces Microalbuminuria in IGT Patients

Valsartan Reduces Microalbuminuria in IGT Patients

Valsartan reduced the incidence of microalbuminuria in IGT without increasing the incidence of hyperkalemia or renal dysfunction compared with placebo.

T2DM Microvascular Complications Linked to Periodontitis Severity

T2DM Microvascular Complications Linked to Periodontitis Severity

Poor glycemic control linked to increased prevalence and severity of periodontitis.

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

Liraglutide Found to Reduce Albuminuria in Diabetes Patients

Use of the glucagon-like peptide-1 receptor agonist lowered 24-hour urinary albumin excretion rate by 32% over 12 weeks versus placebo.

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Low HDL-C, High Triglycerides Up Risk for Diabetic Kidney Disease

Findings in large cohort of patients with diabetes over 4 years of follow-up.

Advanced Glycation End-Products Predict Renal Function Decline

Advanced Glycation End-Products Predict Renal Function Decline

AGEs improve RFL prediction in American-Indians with type 2 diabetes.

Diabetic Kidney Disease Rates in US Hold Steady

Diabetic Kidney Disease Rates in US Hold Steady

No change in overall prevalence from 1988 to 2014; decrease in albuminuria, increase in reduced eGFR.

Slower Kidney Disease Progression Observed With Empagliflozin Use

Slower Kidney Disease Progression Observed With Empagliflozin Use

Incident or worsening nephropathy was observed in 12.7% of patients receiving empagliflozin compared with 18.8% of those receiving placebo.

Diabetes Remission From Surgery Cuts Microvascular Disease Risk

Diabetes Remission From Surgery Cuts Microvascular Disease Risk

Length of time spent in remission inversely related to risk of microvascular disease.

Kidney Function Decline Tied to CV Events in Diabetics

Kidney Function Decline Tied to CV Events in Diabetics

Renal function decline is independent factor for cardiovascular risk in patients with type 2 diabetes.

Study: Diabetic Nephropathy Underdiagnosed

Study: Diabetic Nephropathy Underdiagnosed

Diabetic nephropathy lesions may develop prior to the onset of clinical findings.

Acthar Gel May Be an Option for Nephrotic Syndrome

Acthar Gel May Be an Option for Nephrotic Syndrome

Athcar gel may be a treatment option for patients with treatment-resistant nephrotic syndrome.

Diabetes, Diabetic Nephropathy Increased in Children

Diabetes, Diabetic Nephropathy Increased in Children

Increase in prevalence from 2002-2013, with highest prevalence among those aged 12 to less than 18 years.

Patiromer Benefits High-Risk Hyperkalemic Patients

Patiromer Benefits High-Risk Hyperkalemic Patients

The medication significantly decreased potassium levels over 52 weeks in patients with resistant hypertension and diabetic kidney disease.

Urinary Potassium Linked to Lower ESRD, CVD Risk in Diabetes

Urinary Potassium Linked to Lower ESRD, CVD Risk in Diabetes

Higher urinary potassium excretion, not sodium excretion, tied to lower risk of primary end point.

Renal Biomarkers Predict Diabetes Outcomes

Renal Biomarkers Predict Diabetes Outcomes

AKI, albuminuria, eGFR considered separately or together can predict adverse outcomes in diabetes.

Vascular Lesions in Renal Biopsy Specimens Predict CV Events

Vascular Lesions in Renal Biopsy Specimens Predict CV Events

Significant association found in patients with diabetic nephropathy.

Adding Finerenone Improves Albuminuria in Diabetic Nephropathy

Adding Finerenone Improves Albuminuria in Diabetic Nephropathy

Hyperkalemia occurred in just 1.8% of patients taking finerenone 7.5 to 20 mg daily.

Nonalbuminuric CKD May Increase Mortality in Type 1 Diabetes

Nonalbuminuric CKD May Increase Mortality in Type 1 Diabetes

Nonalbuminuric chronic kidney disease was linked to increases in all-cause and cardiovascular mortality, but not albuminuria or end-stage renal disease.

Poorly Controlled Diabetes May Increase Dementia

Poorly Controlled Diabetes May Increase Dementia

Older patients with more diabetes complications have greater cognitive decline, study finds.

Diabetic Kidney Disease Linked to High Uric Acid

Diabetic Kidney Disease Linked to High Uric Acid

Increased uric acid levels were correlated with decreased HbA1c and increased prevalence of diabetic kidney disease, study finds.

Mild CKD and Tight Glucose Control Increase Risks in Diabetics

Mild CKD and Tight Glucose Control Increase Risks in Diabetics

Intense glycemic control was significantly linked to higher risks of cardiovascular and all-cause mortality

Women with Type 1 Diabetes Fare Worse Than Men

Women with Type 1 Diabetes Fare Worse Than Men

Among the increased risks, women with the disease had an 86% higher chance of dying from cardiovascular disease than men.

Diabetic Nephropathy More Common Than Previously Thought

Diabetic Nephropathy More Common Than Previously Thought

Researchers in the Netherlands report results from an autopsy study of diabetic nephropathy patients.

Diabetic Nephropathy Linked to Hypothyroidism

Diabetic Nephropathy Linked to Hypothyroidism

Researchers find an independent association in a study of Japanese patients with type 2 diabetes.

Fewer Ophthalmologists Linked to Poorer Retinopathy Treatment

Fewer Ophthalmologists Linked to Poorer Retinopathy Treatment

Public health efforts needed to ensure adequate access to ophthalmologists.

Abatacept May Prevent Kidney Disease Advance in Diabetics

Abatacept May Prevent Kidney Disease Advance in Diabetics

The drug maintained kidney function in mice with diabetic nephropathy.

Gluten-Free Diet Helps to Prevent Diabetic Nephropathy

Gluten-Free Diet Helps to Prevent Diabetic Nephropathy

A trial of a gluten-free diet presents no inherent risk for patients starting to exhibit microvascular damage.

Diabetes-Related ESRD Risk Higher Among Indigenous Canadians

Among Canadian diabetics, end-stage renal disease is almost three times more likely to development among First Nation adults.

Diabetic Nephropathy Not Improved by Dual Regimen

ACE inhibitor plus ARB failed to slow disease progression but increased acute kidney injury risk.

Most Elderly ESRD Cases in Singapore Due to Diabetes

Diabetic nephropathy was the cause of ESRD in 62.8% of patients, study shows.

Diabetic Kidney Disease Linked to Reduced Mitochondrial Function

New treatments that restore and increase mitochondrial function and content could ameliorate or even arrest CKD, according to investigators.

ESRD Delayed With Multifactorial Intervention

Nearly twofold decrease observed in the proportion of patients with advanced diabetic nephropathy who progress to end-stage renal disease.

Creatinine Excretion Rate Hikes Mortality Risk in T2DM

Creatinine Excretion Rate Hikes Mortality Risk in T2DM

Lower creatinine excretion rate linked to higher all-cause mortality in type 2 diabetes, nephropathy

Novel Racial/Ethnic Differences Found in Diabetic Kidney Disease

Novel Racial/Ethnic Differences Found in Diabetic Kidney Disease

Minorities more likely to have proteinuric DKD; less likely to have nonproteinuric DKD.

Proteinuric Diabetic Kidney Disease More Likely in Minorities

Minorities also are less likely than non-Hispanic whites to have nonproteinuric diabetic kidney disease.

Dual Combo Not Superior for Slowing Renal Function Loss

ACE inhibitor plus an angiotensin receptor blocker was not more effective than either drug alone in patients with diabetic nephropathy.

Reduced Sodium Enhances ARB Effects

Improved renal and cardiovascular protection observed in patients with type 2 diabetic nephropathy.

Herbal Drug May Reduce Proteinuria

Silymarin significantly decreased UACR compared with placebo in patients with diabetic nephropathy.

ESRD More Likely than Death for Patients with Diabetic Nephropathy

Patients with type 2 diabetic nephropathy are more likely to progress to end-stage renal disease (ESRD) than die, according to investigators.

Greater Risk of Nephropathy in Hypertensive Diabetes Reported

ACE inhibitor of ARB use decreased progression risk in patients with macroalbuminuria at baseline.

Podocytes May Need Insulin to Maintain Kidney Function

Podocytes demonstrate a strong reliance on insulin to function properly, according to a study published in Cell Metabolism (2010;12:329-340).

UACR Varies by Season in Diabetic Nephropathy

Researchers have found a seasonal variation in urinary albumin-to-creatinine ratio (UACR) in Japanese patients with type 2 diabetes and early nephropathy, with the highest values in winter and the lowest in summer.

Morning Urine Test Better For Renal Risk Assessment

The albumin:creatinine ratio in the first urine excreted in the morning is better than 24-hour urinary albumin excretion in determining the risk for renal events in patients with type 2 diabetes and nephropathy, data show.

Vitamin B Could Have a Down Side in Patients with Diabetic Nephropathy

Patients with diabetic nephropathy should avoid taking high doses of B vitamins to lower homocysteine levels.

Megadosage Candesartan Beneficial

Renal disease patients who have persistent proteinuria despite treatment with the highest approved dosage of the angiotensin receptor blocker candesartan may benefit from higher dosages, a Canadian study finds.

U.K. Team: GFR Estimates Important

SAN FRANCISCO—British researchers have endorsed U.S. guidelines stating that screening diabetic patients for renal disease should involve estimated glomerular filtration rate (eGFR) in addition to testing for albuminuria.

Renoprotective Effect of Aliskiren Shown

Aliskiren, an oral direct renin inhibitor, may have renoprotective effects that are independent of its BP-lowering effect in patients with type 2 diabetic nephropathy who are receiving the maximal recommended renoprotective treatment and optimal antihypertensive therapy, researchers report.

Intensive Glucose Control Found to Protect Kidneys

Intensive glucose control with gliclazide (modified release) and other agents reduced the risk of nephropathy by one fifth in a large study of patients with type 2 diabetes.

More Type 2 Diabetics Face ESRD

End-stage renal disease (ESRD) is affecting a growing proportion of type 2 diabetics in Australia and New Zealand, a study found.

Telmisartan Offers Better Renoprotection

CHICAGO—Telmisartan (Micardis HCT), a novel angiotensin receptor blocker (ARB), and the older ARB losartan have similar BP-lowering efficacy in hypertensive patients with diabetic nephropathy, but treatment with the new agent is associated with larger reductions in proteinuria, new findings show.

Enlarged Kidneys Predict Nephropathy

Renal hypertrophy is a major factor in the development of diabetic nephropathy in patients with type 1 diabetes.

Further Data on Diabetic Retinopathy Drug Requested

Eli Lilly and Company has received an approvable letter from the FDA requesting additional supporting data for its new drug application for ruboxistaurin mesylate (proposed trade name: Arxxant), Lilly's investigational oral therapy for diabetic retinopathy.

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